About: Lorazepam

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B54D8-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54D9-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54DA-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54DD-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54DE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54DF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54E0-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54E1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54E2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54DB-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54DC-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Kemper N, Poser W, Poser S: [Benzodiazepine dependence: addiction potential of the benzodiazepines is greater than previously assumed (author's transl)] Dtsch Med Wochenschr. 1980 Dec 5;105(49):1707-12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7439058 # Lader M: Short-term versus long-term benzodiazepine therapy. Curr Med Res Opin. 1984;8 Suppl 4:120-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6144459 # Maltais F, Laberge F, Laviolette M: A randomized, double-blind, placebo-controlled study of lorazepam as premedication for bronchoscopy. Chest. 1996 May;109(5):1195-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8625666 # Heisterkamp DV, Cohen PJ: The effect of intravenous premedication with lorazepam (ativan), pentobarbitone or diazepam on recall. Br J Anaesth. 1975 Jan;47(1):79-81. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/238548 # Milligan DW, Howard MR, Judd A: Premedication with lorazepam before bone marrow biopsy. J Clin Pathol. 1987 Jun;40(6):696-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3611398 # FDA label (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Parenteral administration = 14±5 hours; Oral administration = 2 hours. (en)
http://linked.open...ugbank/indication	For the management of anxiety disorders, and for treatment of status epilepticus. (en)
http://linked.open...bank/manufacturer	Amneal pharmaceuticals Cardinal Health A-S Medication Solutions LLC Boca Pharmacal Baxter healthcare corp anesthesia critical care Akorn inc Baxter healthcare corp anesthesia and critical care Actavis Group Ivax pharmaceuticals inc sub teva pharmaceuticals usa Apotex Inc. Atlantic Biologicals Corporation Aurobindo Pharma Ltd. Boca Pharmacal Cardinal Health Bedford laboratories Biovail laboratories inc Cipla Ltd. A-S Medication Solutions LLC American therapeutics inc Sandoz Dept Health Central Pharmacy Ivax pharmaceuticals inc sub teva pharmaceuticals usa Direct Dispensing Inc. Dispensing Solutions Aton pharma inc Endo Pharmaceuticals Inc. Epic Pharma LLC Golden State Medical Supply Inc. Group Health Cooperative H.J. Harkins Co. Inc. Heartland Repack Services LLC
sameAs	Lorazepam
Title	Lorazepam (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00186/identifier/chemspider/3821 http://linked.opendata.cz/resource/drugbank/drug/DB00186/identifier/drugbank/DB00186 http://linked.opendata.cz/resource/drugbank/drug/DB00186/identifier/kegg-drug/D00365 http://linked.opendata.cz/resource/drugbank/drug/DB00186/identifier/national-drug-code-directory/0054-3532-44 http://linked.opendata.cz/resource/drugbank/drug/DB00186/identifier/pubchem-compound/3958 http://linked.opendata.cz/resource/drugbank/drug/DB00186/identifier/pubchem-substance/46508468 http://linked.opendata.cz/resource/drugbank/drug/DB00186/identifier/chebi/52993 http://linked.opendata.cz/resource/drugbank/drug/DB00186/identifier/pharmgkb/PA450267 http://linked.opendata.cz/resource/drugbank/drug/DB00186/identifier/wikipedia/Lorazepam
http://linked.open...mechanismOfAction	Lorazepam binds to an allosteric site on GABA-A receptors, which are pentameric ionotropic receptors in the CNS. Binding potentiates the effects of the inhibitory neurotransmitter GABA, which upon binding opens the chloride channel in the receptor, allowing chloride influx and causing hyperpolerization of the neuron. (en)
http://linked.open...drugbank/packager	Actavis Group Aidarex Pharmacuticals LLC Akorn Inc. Amerisource Health Services Corp. Amneal Pharmaceuticals Apotheca Inc. A-S Medication Solutions LLC Abraxis pharmaceutical products Bedford Labs Bel mar laboratories inc Centaur Pharmaceuticals Pvt Ltd. Cipla Ltd. Comprehensive Consultant Services Inc. C.O. Truxton Inc. Carlisle Laboratories Inc. Abbott laboratories pharmaceutical products div Abbott laboratories hosp products div Diversified Healthcare Services Inc. Abraxis pharmaceutical products Baxter healthcare corp anesthesia and critical care H.J. Harkins Co. Inc. Heartland Repack Services LLC Hospira Inc. Innoviant Pharmacy Inc. Kaiser Foundation Hospital Lake Erie Medical and Surgical Supply Liberty Pharmaceuticals Major Pharmaceuticals Mckesson Corp. Meda AB Medisca Inc. Murfreesboro Pharmaceutical Nursing Supply Mutual Pharmaceutical Co. Mylan Nucare Pharmaceuticals Inc. Ohm Laboratories Inc. Paddock Labs Pharmaceutical Utilization Management Program VA Inc. Gruppo Lepetit SPA Advanced Pharmaceutical Services Inc.

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