About: Dihomo-gamma-linolenic acid     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5. [PubChem] (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • nutraceutical (en)
http://linked.open...ugbank/indication
  • For nutritional supplementation, also for treating dietary shortage or imbalance (en)
sameAs
Title
  • Dihomo-gamma-linolenic acid (en)
adms:identifier
http://linked.open...mechanismOfAction
  • DHLA (or DGLA) is a precursor in the synthesis of prostaglandin E1 (PGE1) as well as the series-3 prostaglandins. It also serves as a precursor in the synthesis of eicosapentaenoic acid (EPA). EPA is a precursor of the series-3 prostaglandins, the series-5 leukotrienes and the series-3 thromboxanes. These eicosanoids have anti-thrombogenic, anti-inflammatory and anti-atherogenic properties. PGE1 inhibits platelet aggregation and has a vasodilation action. DHLA has also been shown to reduce the production/activity of tumor necrosis factor alpha. (en)
http://linked.open.../drugbank/synonym
  • gamma-Homolinolenic acid (en)
  • (Z,Z,Z)-8,11,14-Eicosatrienoic acid (en)
  • 8,11,14-Eicosatrienoic Acid (en)
  • DGLA (en)
  • Homo-gamma-linolenic acid (en)
  • (8Z,11Z,14Z)-Icosatrienoic acid (en)
  • (Z,Z,Z)-8,11,14-Icosatrienoate (en)
  • (Z,Z,Z)-8,11,14-Icosatrienoic acid (en)
  • 20:3, n-6,9,12 all-cis (en)
  • 8c,11c,14c-Eicosatriensaeure (en)
  • 8c,11c,14c-eicosatrienoic acid (en)
  • C20:3, n-6,9,12 all-cis (en)
  • Dihomo-γ-linolenic acid (en)
  • Homo-gamma-linolensaeure (en)
  • all-cis-8,11,14-eicosatrienoic acid (en)
  • all-cis-8,11,14-icosatrienoic acid (en)
  • all-cis-Eicosa-8,11,14-triensaeure (en)
  • all-cis-eicosa-8,11,14-trienoic acid (en)
  • all-cis-icosa-8,11,14-trienoic acid (en)
  • cis,cis,cis-8,11,14-eicosatrienoic acid (en)
  • eicosa-8Z,11Z,14Z-trienoic acid (en)
http://linked.open...ynthesisReference
  • Hiroshi Kawashima, "Process for production of dihomo-gamma-linolenic acid and lipid containing same." U.S. Patent US20010021522, issued September 13, 2001. (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 1783-84-2 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
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