About: Glycine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
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http://linked.open...gbank/description	A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4B16-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4B17-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en) nutraceutical (en)
http://linked.open...ugbank/indication	Supplemental glycine may have antispastic activity. Very early findings suggest it may also have antipsychotic activity as well as antioxidant and anti-inflammatory activities. (en)
http://linked.open...bank/manufacturer	Baxter healthcare corp B braun medical inc Hospira inc
sameAs	Glycine
Title	Glycine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00145/identifier/chebi/15428 http://linked.opendata.cz/resource/drugbank/drug/DB00145/identifier/chemspider/730 http://linked.opendata.cz/resource/drugbank/drug/DB00145/identifier/drugbank/DB00145 http://linked.opendata.cz/resource/drugbank/drug/DB00145/identifier/guide-to-pharmacology/727 http://linked.opendata.cz/resource/drugbank/drug/DB00145/identifier/iuphar/727 http://linked.opendata.cz/resource/drugbank/drug/DB00145/identifier/kegg-compound/C00037 http://linked.opendata.cz/resource/drugbank/drug/DB00145/identifier/kegg-drug/D00011 http://linked.opendata.cz/resource/drugbank/drug/DB00145/identifier/national-drug-code-directory/0338-0289-47 http://linked.opendata.cz/resource/drugbank/drug/DB00145/identifier/pdb/GLY http://linked.opendata.cz/resource/drugbank/drug/DB00145/identifier/pharmgkb/PA449789 http://linked.opendata.cz/resource/drugbank/drug/DB00145/identifier/pubchem-compound/750 http://linked.opendata.cz/resource/drugbank/drug/DB00145/identifier/pubchem-substance/46508219 http://linked.opendata.cz/resource/drugbank/drug/DB00145/identifier/wikipedia/Glycine
http://linked.open...mechanismOfAction	In the CNS, there exist strychnine-sensitive glycine binding sites as well as strychnine-insensitive glycine binding sites. The strychnine-insensitive glycine-binding site is located on the NMDA receptor complex. The strychnine-sensitive glycine receptor complex is comprised of a chloride channel and is a member of the ligand-gated ion channel superfamily. The putative antispastic activity of supplemental glycine could be mediated by glycine's binding to strychnine-sensitive binding sites in the spinal cord. This would result in increased chloride conductance and consequent enhancement of inhibitory neurotransmission. The ability of glycine to potentiate NMDA receptor-mediated neurotransmission raised the possibility of its use in the management of neuroleptic-resistant negative symptoms in schizophrenia. <br/>Animal studies indicate that supplemental glycine protects against endotoxin-induced lethality, hypoxia-reperfusion injury after liver transplantation, and D-galactosamine-mediated liver injury. Neutrophils are thought to participate in these pathologic processes via invasion of tissue and releasing such reactive oxygen species as superoxide. In vitro studies have shown that neutrophils contain a glycine-gated chloride channel that can attenuate increases in intracellular calcium and diminsh neutrophil oxidant production. This research is ealy-stage, but suggests that supplementary glycine may turn out to be useful in processes where neutrophil infiltration contributes to toxicity, such as ARDS. (en)
http://linked.open...drugbank/packager	Amend B. Braun Melsungen AG Baxter International Inc. Chattem Chemicals Inc. GlaxoSmithKline Inc. Hospira Inc. Mallinckrodt Inc. Pharmelle LLC
http://linked.open.../drugbank/synonym	Glycine (en) Glycocoll (en) Aminoacetic acid (en) Aminoethanoic acid (en) Gly (en) G (en) Aminoessigsaeure (en) Glycin (en) Glykokoll (en) Glyzin (en) H2N-CH2-COOH (en) Hgly (en) Leimzucker (en)
http://linked.open...drugbank/toxicity	ORL-RAT LD<sub>50</sub> 7930 mg/kg, SCU-RAT LD<sub>50</sub> 5200 mg/kg, IVN-RAT LD<sub>50</sub> 2600 mg/kg, ORL-MUS LD<sub>50</sub> 4920 mg/kg; Doses of 1 gram daily are very well tolerated. Mild gastrointestinal symptoms are infrequently noted. In one study doses of 90 grams daily were also well tole. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/40-36-00
http://linked.open...ynthesisReference	Koichi Niimura, Takako Kawabe, Takao Ando, Kenichi Saito, "Phenylalanine-glycine compounds having anti-tumor activity, process for preparation thereof, and pharmaceutical composition containing said compounds." U.S. Patent US5411964, issued August, 1908. (en)
foaf:page	http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/gly_0127.shtml
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http://linked.open...l/drug/hasATCCode	Glycine
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http://linked.open...ugbank/absorption	Absorbed from the small intestine via an active transport mechanism. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	56-40-6 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Glycine 1.5% irrigation Amino acetic acid powder BuPROPion HCl 200 mg 12 Hour tablet Diluent for flolan vial
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