About: L-Lysine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	L-Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. L-Lysine is a base, as are arginine and histidine. The ε-amino group often participates in hydrogen bonding and as a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell. (en)
http://linked.open...generalReferences	# Griffith RS, Norins AL, Kagan C: A multicentered study of lysine therapy in Herpes simplex infection. Dermatologica. 1978;156(5):257-67. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/640102 (en)
http://linked.open...gy/drugbank/group	approved (en) nutraceutical (en)
http://linked.open...ugbank/indication	Supplemental L-lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity. (en)
sameAs	L-Lysine
Title	L-Lysine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00123/identifier/chebi/18019 http://linked.opendata.cz/resource/drugbank/drug/DB00123/identifier/drugbank/DB00123 http://linked.opendata.cz/resource/drugbank/drug/DB00123/identifier/kegg-compound/C00047 http://linked.opendata.cz/resource/drugbank/drug/DB00123/identifier/kegg-drug/D02304 http://linked.opendata.cz/resource/drugbank/drug/DB00123/identifier/pdb/LYS http://linked.opendata.cz/resource/drugbank/drug/DB00123/identifier/pharmgkb/PA450280 http://linked.opendata.cz/resource/drugbank/drug/DB00123/identifier/wikipedia/L-Lysine
http://linked.open...mechanismOfAction	Proteins of the herpes simplex virus are rich in L-arginine, and tissue culture studies indicate an enhancing effect on viral replication when the amino acid ratio of L-arginine to L-lysine is high in the tissue culture media. When the ratio of L-lysine to L-arginine is high, viral replication and the cytopathogenicity of herpes simplex virus have been found to be inhibited. L-lysine may facilitate the absorption of calcium from the small intestine. (en)
http://linked.open...drugbank/packager	Basic Organics CVS Pharmacy Actavis elizabeth llc Barr laboratories inc Dava pharmaceuticals inc Lupin Pharmaceuticals Inc. Ferndale laboratories inc Halsey drug co inc Ivax pharmaceuticals inc sub teva pharmaceuticals usa Martec usa llc
http://linked.open.../drugbank/synonym	(S)-2,6-diaminohexanoic acid (en) (S)-lysine (en) (S)-α,ε-diaminocaproic acid (en) L-lys (en) LYS (en) lysine acid (en) 6-ammonio-L-norleucine (en)
http://linked.open...ynthesisReference	Joseph Michael Stevens, Thomas P. Binder, "Process for making granular L-lysine." U.S. Patent US5990350, issued 0000. (en)
foaf:page	http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/lly_0166.shtml
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http://linked.open...ugbank/absorption	Absorbed from the lumen of the small intestine into the enterocytes by an active transport process (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	56-87-1 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Cayston 75 mg inhal solution Neoprofen 20 mg/2 ml vial Lysine 500 mg tablet CVS Pharmacy l-lysine 500 mg tablet L-lysine 1000 mg tablet L-lysine 500 mg tablet Diazemuls 5 mg/ml Emulsion Ra l-lysine 1000 mg tablet L-lysine ointment Diazepam powder
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