About: Daclizumab     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • Humanized IgG1 Mab that binds to the human interleukin-2 receptor (anti-Tac or anti-CD25). Daclizumab is a composite of human (90%) and murine (10%) antibody sequences. The human sequences were derived from the constant domains of human IgG1 and the variable framework regions of the Eu myeloma antibody. The murine sequences were derived from the complementarity-determining regions of a murine anti-Tac antibody. (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • investigational (en)
http://linked.open...drugbank/halfLife
  • 11-38 days (en)
http://linked.open...ugbank/indication
  • Zenapax is a humanized monoclonal antibody used for prevention of renal transplant rejection (en)
sameAs
Title
  • Daclizumab (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Zenepax binds with high-affinity to the Tac subunit of the high-affinity IL-2 receptor complex and inhibits IL-2 binding. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes. (en)
http://linked.open...drugbank/packager
http://linked.open.../drugbank/synonym
  • Anti-IL-2 (en)
  • Humanized antiCD25 (en)
  • Ig gamma-1 chain C region (en)
http://linked.open.../drug/hasAHFSCode
foaf:page
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...l/drug/hasATCCode
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 152923-56-3 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...nk/Hydrophobicity
http://linked.open...Isoelectric-Point
http://linked.open...ank/Melting-Point
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