About: Natalizumab

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Humanized IgG4k monoclonal antibody produced in murine myeloma cells. Natalizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to a4-integrin. Natalizumab was voluntarily withdrawn from U.S. market because of risk of Progressive multifocal leukoencephalopathy (PML). It was returned to market July, 2006. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B45EC-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B45ED-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Ghosh S, Goldin E, Gordon FH, Malchow HA, Rask-Madsen J, Rutgeerts P, Vyhnalek P, Zadorova Z, Palmer T, Donoghue S: Natalizumab for active Crohn's disease. N Engl J Med. 2003 Jan 2;348(1):24-32. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12510039 # Patent Information "Link":http://www.patentstorm.us/patents/5840299/fulltext.html (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	11 ± 4 days (en)
http://linked.open...ugbank/indication	For treatment of multiple sclerosis. (en)
sameAs	Natalizumab
Title	Natalizumab (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00108/identifier/drugbank/DB00108 http://linked.opendata.cz/resource/drugbank/drug/DB00108/identifier/national-drug-code-directory/59075-730-15 http://linked.opendata.cz/resource/drugbank/drug/DB00108/identifier/pharmgkb/PA164747191 http://linked.opendata.cz/resource/drugbank/drug/DB00108/identifier/wikipedia/Natalizumab
http://linked.open...mechanismOfAction	Binds to the α4-subunit of α4b 1 and α4b 7 integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the α4-mediated adhesion of leukocytes to their counter-receptor(s). (en)
http://linked.open...drugbank/packager	Biogen Idec Inc. Pfizer Inc. Hospira Inc.
http://linked.open.../drugbank/synonym	Anti-VLA4 (en) Anti-alpha4 integrin (en)
http://linked.open...umeOfDistribution	* 5.7 ± 1.9 L [Multiple Sclerosis (MS) Patients] * 5.2 ± 2.8 L [Crohn's Disease (CD) Patients] (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/92-00-00
foaf:page	http://www.drugs.com/cdi/natalizumab.html http://www.rxlist.com/cgi/generic/tysabri.htm
http://linked.open...l/drug/hasATCCode	Natalizumab
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	189261-10-7 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 16 +/- 5 mL/hour [patients with MS who did not have PML receiving the repeat IV administration of a 300 mg dose] * 22 +/- 22 mL/hour [Patients with Crohn's Disease receiving the repeat IV administration of a 300 mg dose] (en)
http://linked.open...gbank/containedIn	Nuprin muscle & joint patch
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B45EE-363D-11E5-9242-09173F13E4C5

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