About: Coagulation Factor IX

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Human Factor IX protein, produced by recombinant DNA technology for use in therapy of factor IX deficiency, known as hemophilia B or Christmas disease. Coagulation Factor IX (Recombinant) is a glycoprotein with an approximate molecular mass of 55,000 Da consisting of 415 amino acids in a single chain. It has a primary amino acid sequence that is identical to the Ala 148 allelic form of plasma-derived factor IX. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4531-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4532-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# BIGGS R, DOUGLAS AS, MACFARLANE RG, DACIE JV, PITNEY WR, MERSKEY: Christmas disease: a condition previously mistaken for haemophilia. Br Med J. 1952 Dec 27;2(4799):1378-82. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12997790 # Kurachi K, Davie EW: Isolation and characterization of a cDNA coding for human factor IX. Proc Natl Acad Sci U S A. 1982 Nov;79(21):6461-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6959130 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	19.4 ± 5.4 hours (range from 11 to 36 hours) (en)
http://linked.open...ugbank/indication	For treatment of hemophilia (Christmas disease). (en)
sameAs	Coagulation Factor IX
Title	Coagulation Factor IX (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00100/identifier/drugbank/DB00100 http://linked.opendata.cz/resource/drugbank/drug/DB00100/identifier/genbank/K02402 http://linked.opendata.cz/resource/drugbank/drug/DB00100/identifier/kegg-compound/C03101 http://linked.opendata.cz/resource/drugbank/drug/DB00100/identifier/national-drug-code-directory/0053-7668-02 http://linked.opendata.cz/resource/drugbank/drug/DB00100/identifier/uniprotkb/P00740 http://linked.opendata.cz/resource/drugbank/drug/DB00100/identifier/pharmgkb/PA164744952 http://linked.opendata.cz/resource/drugbank/drug/DB00100/identifier/wikipedia/Factor_IX
http://linked.open...mechanismOfAction	Coagulation Factor IX is an important protein in the process of hemostasis and normal blood clotting. Factor IX is plays an important intermediate role in the blood coagulation cascade. It is located within the blood plasma as a zymogen, an antecedent to enzymatic function, in its inactivated state. Factor IX is dependent on the presence of Vitamin K, and is activated to a serine protease by the function of Coagulation Factor XIa. Factor XIa cleaves the peptide bond associated with protein activation in Factor IX, leaving Factor IX with two exposed chains, a light chain and a heavy chain. These two chains are held together by several disulfide bonds that reinforce the structure of Factor IX's activated form. After being activated, Factor IX forms a complex with calcium ions, membrane phospholipids and Coagulation Factor VIII to activate Coagulation Factor X. The activation of Factor X then performs a similarly integral step in the blood coagulation cascade. The ultimate result of phenotypically normal coagulation factors is the creation of platelets for normal blood clotting. (en)
http://linked.open...drugbank/packager	CSL Behring LLC Grifols SA Hospira Inc. Vangard Labs Inc.
http://linked.open.../drugbank/synonym	Christmas factor (en) Coagulation factor IX precursor (en) PTC (en) Plasma thromboplastin component (en)
http://linked.open...ynthesisReference	Volker Schellenberger, Joshua Silverman, Willem Stemmer, Chia-wei Wang, Benjamin Spink, Nathan Geething, Wayne To, "Coagulation factor IX compositions and methods of making and using same." U.S. Patent US20110046060, issued February 24, 2011. (en)
foaf:page	http://www.drugs.com/cdi/coagulation-factor-ix-injection-human.html http://www.rxlist.com/cgi/generic2/factorix.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4537-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4536-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Coagulation factor IX
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	9001-28-9 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Benefix 1000 unit vial Benefix 250 unit vial Benefix 500 unit vial Benefix 2000 unit vial Mononine 1000 unit vial Mononine 500 unit vial Alphanine sd 250-1500 unit vial
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4534-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B4535-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B4533-363D-11E5-9242-09173F13E4C5

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