About: Efalizumab

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. (en)
http://linked.open...generalReferences	# "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8943405 # Descamps V: [Efalizumab] Ann Dermatol Venereol. 2006 Aug-Sep;133(8-9 Pt 1):666-78. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17053736 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	5 days (en)
http://linked.open...ugbank/indication	For the treatment of adult patients with moderate to severe chronic plaque psoriasis, who are candidates for phototherapy or systemic therapy. (en)
sameAs	Efalizumab
Title	Efalizumab (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00095/identifier/drugbank/DB00095 http://linked.opendata.cz/resource/drugbank/drug/DB00095/identifier/pharmgkb/PA164748817 http://linked.opendata.cz/resource/drugbank/drug/DB00095/identifier/wikipedia/Efalizumab
http://linked.open...mechanismOfAction	Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes. As a result efalizumab decreases cell surface expression of CD11a. (en)
http://linked.open...drugbank/packager	Bausch & Lomb Inc.
http://linked.open.../drugbank/synonym	Raptiva (en) anti alphaL integrin (en) antiCD11 alpha (en) hu1124 (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/84-92-00
foaf:page	http://www.drugs.com/cdi/efalizumab.html http://www.rxlist.com/cgi/generic3/raptiva.htm
http://linked.open...l/drug/hasATCCode	Efalizumab
http://linked.open...ugbank/absorption	Average efalizumab bioavailability following subcutaneous administration was estimated at 30 to 50%. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	214745-43-4 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B44E9-363D-11E5-9242-09173F13E4C5

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