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rdf:type
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http://linked.open...gbank/description
| - Humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). Campath is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium containing neomycin. (en)
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http://linked.open...y/drugbank/dosage
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http://linked.open...generalReferences
| - # Hale G, Bright S, Chumbley G, Hoang T, Metcalf D, Munro AJ, Waldmann H: Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. Blood. 1983 Oct;62(4):873-82. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6349718 # Riechmann L, Clark M, Waldmann H, Winter G: Reshaping human antibodies for therapy. Nature. 1988 Mar 24;332(6162):323-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3127726 # IGMT "Link":http://imgt.cines.fr/3Dstructure-DB/cgi/details.cgi?pdbcode=1BEY # IGMT "Link":http://imgt.cines.fr/3Dstructure-DB/cgi/details.cgi?pdbcode=1CE1 # IGMT "Link":http://imgt.cines.fr/3Dstructure-DB/cgi/details.cgi?pdbcode=8005 (en)
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http://linked.open...gy/drugbank/group
| - approved (en)
- investigational (en)
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http://linked.open...drugbank/halfLife
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http://linked.open...ugbank/indication
| - Alemtuzumab (Campath) is a monoclonal antibody therapy used for treatment of B-cell chronic lymphocytic leukemia. (en)
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sameAs
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Title
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adms:identifier
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http://linked.open...mechanismOfAction
| - Campath binds to the CD52 antigen present on most B and T lymphocytes. This binding leads to antibody-dependent lysis of leukemic cells. (en)
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http://linked.open...drugbank/packager
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http://linked.open...y/drugbank/patent
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http://linked.open...umeOfDistribution
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http://linked.open.../drug/hasAHFSCode
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foaf:page
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http://linked.open...Molecular-Formula
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http://linked.open.../Molecular-Weight
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http://linked.open...l/drug/hasATCCode
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http://linked.open...casRegistryNumber
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http://linked.open...gbank/containedIn
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http://linked.open...nk/Hydrophobicity
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http://linked.open...Isoelectric-Point
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http://linked.open...ank/Melting-Point
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