About: Interferon beta-1a

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence of Avonex is identical to that of natural human interferon beta. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B42A1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B42A2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B42A3-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B42A4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B42A5-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B42A6-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B42A7-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B42A8-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B42A9-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B42AA-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B42AB-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B42AC-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	10 hrs (en)
http://linked.open...ugbank/indication	For treatment of relapsing/remitting multiple sclerosis, also for condyloma acuminatum (en)
http://linked.open...bank/manufacturer	Ben Venue Laboratories Inc.
sameAs	Interferon beta-1a
Title	Interferon beta-1a (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00060/identifier/drugbank/DB00060 http://linked.opendata.cz/resource/drugbank/drug/DB00060/identifier/genbank/V00534 http://linked.opendata.cz/resource/drugbank/drug/DB00060/identifier/national-drug-code-directory/44087-8822-1 http://linked.opendata.cz/resource/drugbank/drug/DB00060/identifier/uniprotkb/P01574 http://linked.opendata.cz/resource/drugbank/drug/DB00060/identifier/pharmgkb/PA450037 http://linked.opendata.cz/resource/drugbank/drug/DB00060/identifier/wikipedia/Interferon_beta-1a
http://linked.open...mechanismOfAction	Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon beta binds more stably to type I interferon receptors than interferon alpha. (en)
http://linked.open...drugbank/packager	Apotex Inc. Apotheca Inc. A-S Medication Solutions LLC Atlantic Biologicals Corporation Sandoz Allergy Laboratories Inc.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/1341604
http://linked.open.../drugbank/synonym	Fibroblast interferon (en) IFN-beta (en) Interferon beta precursor (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/92-00-00
http://linked.open...ynthesisReference	Heinz-Jurgen Friesen, Sidney Pestka, "Preparation of homogeneous human fibroblast interferon." U.S. Patent US4289689, issued December, 1968. (en)
foaf:page	http://www.drugs.com/cdi/interferon-beta-1a.html http://www.rxlist.com/cgi/generic3/rebif.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B42B0-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B42AF-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Interferon beta-1a
http://linked.open...casRegistryNumber	145258-61-3 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 33-55 L/hour [Healthy SC injection of 60 mcg] (en)
http://linked.open...gbank/containedIn	Rebif 22 mcg/0.5 ml syringe Rebif 44 mcg/0.5 ml syringe Avonex admin pack 30 mcg vial Avonex 4 30 mcg/vial Kit 1 Box = 4 Vials ( 0.5ml Per Vial) Avonex Prefilled (1 Box = 1 Kit = Four 30 mcg/0.5ml Syringes) Box
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B42AD-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B42AE-363D-11E5-9242-09173F13E4C5

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