About: Imiglucerase

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Human Beta-glucocerebrosidase or Beta-D-glucosyl-N-acylsphingosine glucohydrolase E.C. 3.2.1.45. 497 residue protein with N-linked carbohydrates, MW=59.3 kD. Alglucerase is prepared by modification of the oligosaccharide chains of human Beta-glucocerebrosidase. The modification alters the sugar residues at the non-reducing ends of the oligosaccharide chains of the glycoprotein so that they are predominantly terminated with mannose residues (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4258-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Pastores GM, Hughes DA: Gaucher Disease "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20301446 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	3.6-10.4 min (en)
http://linked.open...ugbank/indication	For the treatment of Gaucher's disease (deficiency in glucocerebrosidase) (en)
http://linked.open...bank/manufacturer	Corepharma LLC
sameAs	Imiglucerase
Title	Imiglucerase (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00053/identifier/drugbank/DB00053 http://linked.opendata.cz/resource/drugbank/drug/DB00053/identifier/genbank/M16328 http://linked.opendata.cz/resource/drugbank/drug/DB00053/identifier/kegg-drug/D02810 http://linked.opendata.cz/resource/drugbank/drug/DB00053/identifier/national-drug-code-directory/58468-4663-1 http://linked.opendata.cz/resource/drugbank/drug/DB00053/identifier/uniprotkb/P04062 http://linked.opendata.cz/resource/drugbank/drug/DB00053/identifier/pharmgkb/PA164742934 http://linked.opendata.cz/resource/drugbank/drug/DB00053/identifier/wikipedia/Imiglucerase
http://linked.open...mechanismOfAction	Imiglucerase catalyzes the hydrolysis of the glycolipid, glucocerebroside, to glucose and ceramide as part of the normal degradation pathway for membrane lipids. (en)
http://linked.open...drugbank/packager	Comfortpak Inc.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/5549892
http://linked.open...umeOfDistribution	* 0.09 to 0.15 L/kg (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/44-00-00
foaf:page	http://www.drugs.com/cdi/imiglucerase.html http://www.rxlist.com/cgi/generic2/imiglucerase.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B425C-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B425B-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Imiglucerase
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	143003-46-7 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 14.5 +/- 4.0 mL/min/kg (en)
http://linked.open...gbank/containedIn	Ceredase 80 unit/ml vial Cerezyme 200 unit vial Cerezyme 400 unit vial
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4259-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B425A-363D-11E5-9242-09173F13E4C5

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