About: Aldesleukin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B414E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B414F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4150-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	13 min-85 min (en)
http://linked.open...ugbank/indication	For treatment of adults with metastatic renal cell carcinoma. (en)
sameAs	Aldesleukin
Title	Aldesleukin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00041/identifier/drugbank/DB00041 http://linked.opendata.cz/resource/drugbank/drug/DB00041/identifier/genbank/M11144 http://linked.opendata.cz/resource/drugbank/drug/DB00041/identifier/national-drug-code-directory/0078-0495-61 http://linked.opendata.cz/resource/drugbank/drug/DB00041/identifier/pharmgkb/PA448081 http://linked.opendata.cz/resource/drugbank/drug/DB00041/identifier/uniprotkb/P60569 http://linked.opendata.cz/resource/drugbank/drug/DB00041/identifier/wikipedia/Aldesleukin
http://linked.open...mechanismOfAction	Aldesleukin binds to the IL-2 receptor which leads to heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains, activation of the tyrosine kinase Jak3, and phosphorylation of tyrosine residues on the IL-2R beta chain. These events led to the creation of an activated receptor complex, to which various cytoplasmic signaling molecules are recruited and become substrates for regulatory enzymes (especially tyrosine kinases) that are associated with the receptor. These events stimulate growth and differentiation of T cells. (en)
http://linked.open...drugbank/packager	Bayer Healthcare Allergan inc Ivax pharmaceuticals inc sub teva pharmaceuticals usa Eli lilly and co Mk laboratories inc
http://linked.open...outeOfElimination	The pharmacokinetic profile of Proleukin is characterized by high plasma concentrations following a short IV infusion, rapid distribution into the extravascular space and elimination from the body by metabolism in the kidneys with little or no bioactive protein excreted in the urine. Following the initial rapid organ distribution, the primary route of clearance of circulating proleukin is the kidney. Greater than 80% of the amount of Proleukin distributed to plasma, cleared from the circulation and presented to the kidney is metabolized to amino acids in the cells lining the proximal convoluted tubules. (en)
http://linked.open.../drugbank/synonym	IL-2 (en) Interleukin-2 precursor (en) T-cell growth factor (en) TCGF (en)
http://linked.open...umeOfDistribution	0.18 l/kg (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/10-00-00
http://linked.open...ynthesisReference	Hans-Ake Fabricius, Roland Stahn, "Serum-free and mitogen-free T-cell growth factor and process for making same." U.S. Patent US4464355, issued May, 1971. (en)
foaf:page	http://www.drugs.com/cdi/aldesleukin.html http://www.rxlist.com/cgi/generic2/aldesleukin.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4154-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4153-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Aldesleukin
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	85898-30-2 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Ciloxan 0.3 % Solution Ciprofloxacin hcl 100 mg tablet
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4151-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B4152-363D-11E5-9242-09173F13E4C5

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