About: Sargramostim

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3FBE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3FBF-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...ugbank/indication	For the treatment of cancer and bone marrow transplant (en)
sameAs	Sargramostim
Title	Sargramostim (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00020/identifier/drugbank/DB00020 http://linked.opendata.cz/resource/drugbank/drug/DB00020/identifier/genbank/M13207 http://linked.opendata.cz/resource/drugbank/drug/DB00020/identifier/national-drug-code-directory/50419-002-33 http://linked.opendata.cz/resource/drugbank/drug/DB00020/identifier/uniprotkb/P04141 http://linked.opendata.cz/resource/drugbank/drug/DB00020/identifier/pharmgkb/PA164748631 http://linked.opendata.cz/resource/drugbank/drug/DB00020/identifier/wikipedia/Sargramostim
http://linked.open...mechanismOfAction	Sargramostim binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils (en)
http://linked.open...drugbank/packager	Bayer Healthcare Baxter International Inc. Bristol-Myers Squibb Co. Contract Pharm Cornerstone Pharmacy Cypress Pharmaceutical Inc.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/1341150
http://linked.open.../drugbank/synonym	GM-CSF (en)
http://linked.open...ynthesisReference	Kaname Sugimoto, "Process for the production of human colony-stimulating factor." U.S. Patent US4621050, issued May, 1983. (en)
foaf:page	http://www.drugs.com/cdi/sargramostim.html http://www.rxlist.com/cgi/generic/sargramostim.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3FC2-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3FC1-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Sargramostim
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	83869-56-1 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 420 mL/min/m2 [Normal people with liquid LEUKINE (IV)] * 431 mL/min/m2 [Normal people with lyophilized LEUKINE (IV)] * 549 mL/min/m2 [Normal people with liquid LEUKINE (SC)] * 529 mL/min/m2 [Normal people with lyophilized LEUKINE (SC)] (en)
http://linked.open...gbank/containedIn	Leukine 250 mcg vial Bio-immunex capsule
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B3FC0-363D-11E5-9242-09173F13E4C5

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