About: Pegfilgrastim

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	PEGylated (at N terminus) form of human G-CSF (Granulocyte colony stimulating factor), 175 residues, produced from E. coli via bacterial fermentation. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3FAF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3FB0-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Yang BB, Kido A: Pharmacokinetics and pharmacodynamics of pegfilgrastim. Clin Pharmacokinet. 2011 May 1;50(5):295-306. doi: 10.2165/11586040-000000000-00000. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/21456630 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	15-80 hrs (en)
http://linked.open...ugbank/indication	Increases leukocyte production, for treatment in non-myeloid cancer, neutropenia and bone marrow transplant (en)
sameAs	Pegfilgrastim
Title	Pegfilgrastim (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00019/identifier/drugbank/DB00019 http://linked.opendata.cz/resource/drugbank/drug/DB00019/identifier/genbank/X03438 http://linked.opendata.cz/resource/drugbank/drug/DB00019/identifier/national-drug-code-directory/55513-190-01 http://linked.opendata.cz/resource/drugbank/drug/DB00019/identifier/uniprotkb/P09919 http://linked.opendata.cz/resource/drugbank/drug/DB00019/identifier/kegg-drug/D06889 http://linked.opendata.cz/resource/drugbank/drug/DB00019/identifier/pharmgkb/PA164781387 http://linked.opendata.cz/resource/drugbank/drug/DB00019/identifier/wikipedia/Pegfilgrastim
http://linked.open...mechanismOfAction	Pegfilgrastim binds to the G-CSF receptor. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Pegfilgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Pegfilgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, pegfilgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase (en)
http://linked.open...drugbank/packager	3m pharmaceuticals inc Astrazeneca lp
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/1339071 http://linked.opendata.cz/resource/drugbank/patent/1341537
http://linked.open...outeOfElimination	Filgrastim is primarily eliminated by the kidney and neutrophils/neutrophil precursors; the latter presumably involves binding of the growth factor to the G-CSF receptor on the cell surface, internalization of the growth factor-receptor complexes via endocytosis, and subsequent degradation inside the cells. Pegylation of filgrastim renders renal clearance insignificant, which was demonstrated in bilaterally nephrectomized rats and confirmed in subjects with renal impairment. As a result, the neutrophil-mediated clearance is the predominant elimination pathway for pegfilgrastim. During chemotherapy-induced neutropenia, the clearance of pegfilgrastim is significantly reduced and the concentration of pegfilgrastim is sustained until onset of neutrophil recovery. (en)
http://linked.open.../drugbank/synonym	Lenograstim (en) G-CSF (en) Granulocyte colony-stimulating factor precursor (en) Pluripoietin (en) N-(3-Hydroxypropyl)Methionylcolony-stimulating Factor (human), 1-Ether with .Alpha.-Methyl-.Omega.-Hydroxypoly(Oxyethylene) (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/20-16-00
foaf:page	http://www.drugs.com/cdi/pegfilgrastim.html http://www.rxlist.com/cgi/generic3/neulasta.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3FB5-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3FB4-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Pegfilgrastim
http://linked.open...casRegistryNumber	208265-92-3 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Neulasta 6 mg/0.6ml Solution 0.6ml Syringe Neulasta 6 mg/0.6 ml syringe
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B3FB2-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B3FB3-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B3FB1-363D-11E5-9242-09173F13E4C5

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