About: Darbepoetin alfa

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3F1B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F1E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F1F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F20-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F21-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F22-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F23-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F24-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F25-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F26-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F27-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F28-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F29-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F1C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F1D-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...ugbank/indication	For the treatment of anemia (from renal transplants or certain HIV treatment) (en)
http://linked.open...bank/manufacturer	Amgen Inc.
sameAs	Darbepoetin alfa
Title	Darbepoetin alfa (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00012/identifier/drugbank/DB00012 http://linked.opendata.cz/resource/drugbank/drug/DB00012/identifier/genbank/X02158 http://linked.opendata.cz/resource/drugbank/drug/DB00012/identifier/uniprotkb/P01588 http://linked.opendata.cz/resource/drugbank/drug/DB00012/identifier/pharmgkb/PA164743138 http://linked.opendata.cz/resource/drugbank/drug/DB00012/identifier/wikipedia/Darbepoetin_alfa
http://linked.open...mechanismOfAction	Darbepoetin alfa stimulates erythropoiesis by the same mechanism as endogenous erythropoietin. Erythropoietin interacts with progenitor stem cells to increase red cell production. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation. (en)
http://linked.open...drugbank/packager	Amgen Inc. Physicians Total Care Inc.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/2147124 http://linked.opendata.cz/resource/drugbank/patent/2165694
http://linked.open.../drugbank/synonym	Epoetin (en) Erythropoietin precursor (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/20-16-00
foaf:page	http://www.drugs.com/cdi/darbepoetin-alfa-albumin.html http://www.rxlist.com/cgi/generic/aranesp.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3F2E-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3F2D-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Darbepoetin alfa
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	11096-26-7 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Aranesp 25 mcg/ml vial Aranesp (Albumin Free) 25 mcg/ml vial Aranesp 40 mcg/ml vial Aranesp 60 mcg/ml vial Aranesp (Albumin Free) 60 mcg/ml vial Aranesp 100 mcg/ml vial Aranesp 200 mcg/ml vial Aranesp 300 mcg/ml vial Aranesp (Albumin Free) 300 mcg/ml vial Aranesp (Albumin Free) 100 mcg/0.5ml Solution (1 Box = Four 0.5ml Syringes) Aranesp (Albumin Free) 100 mcg/ml Solution Four 1ml Vials Per Box Cefotetan 1 gm vial
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B3F2B-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B3F2C-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B3F2A-363D-11E5-9242-09173F13E4C5

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