About: Peginterferon alfa-2a

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Human interferon 2a, is a covalent conjugate of recombinant alfa-2a interferon with a single branched bis-monomethoxy polyethylene glycol (PEG) chain. The PEG moiety is linked at a single site to the interferon alfa moiety via a stable amide bond to lysine. Peginterferon alfa-2a has an approximate molecular weight of 60,000 daltons. Interferon alfa-2a is produced using recombinant DNA technology in which a cloned human leukocyte interferon gene is inserted into and expressed in Escherichia coli. The resultant protein is 165 amino acids. The PEG strand protects the molecule in vivo from proteolytic breakdown, substantially increases its in vivo half-life, and reduces immunogenicity by wrapping around and physically hindering access to the protein portion of the molecule. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3EEC-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3EED-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3EEE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3EEF-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	Terminal half life is 80 hours (range 50 to 140 hours). (en)
http://linked.open...ugbank/indication	For treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma. (en)
sameAs	Peginterferon alfa-2a
Title	Peginterferon alfa-2a (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00008/identifier/drugbank/DB00008 http://linked.opendata.cz/resource/drugbank/drug/DB00008/identifier/genbank/J00207 http://linked.opendata.cz/resource/drugbank/drug/DB00008/identifier/uniprotkb/P01563 http://linked.opendata.cz/resource/drugbank/drug/DB00008/identifier/pharmgkb/PA164749390 http://linked.opendata.cz/resource/drugbank/drug/DB00008/identifier/wikipedia/Peginterferon_alfa-2a
http://linked.open...mechanismOfAction	Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta. (en)
http://linked.open...drugbank/packager	Baxter International Inc. F Hoffmann-La Roche Ltd.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/2172664 http://linked.opendata.cz/resource/drugbank/patent/2203480
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/08-18-20
http://linked.open...k/foodInteraction	Recommended adequate hydration. (en)
foaf:page	http://www.drugs.com/cdi/peginterferon-alfa-2a.html http://www.rxlist.com/cgi/generic3/pegasys.htm
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3EF2-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Peginterferon alfa-2a
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	198153-51-4 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Pegasys 180 mcg/ml vial Pegasys 180 mcg/0.5 ml conv.pk Pegasys (1 Kit = Four 180 mcg/ml Vials Prefilled Syringes) Box
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B3EF1-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B3EF0-363D-11E5-9242-09173F13E4C5

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