| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - Dimetacrine (Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) with imipramine-like effects used in Europe and formerly in Japan for the treatment of depression. (en)
|
| http://linked.open...generalReferences
| - # Ishitani R, Saito E, Kitagawa H: The pharmacological studies on dimetacrine. I. Studies on the absorption, distribution and excretion of H3-labeled dimetacrine in the rat. Jpn J Pharmacol. 1970 Sep;20(3):432-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/5312397 (en)
|
| http://linked.open...gy/drugbank/group
| - approved (en)
- withdrawn (en)
|
| http://linked.open...drugbank/halfLife
| - Approximately 10 hours. (PMID 5312397) (en)
|
| sameAs
| |
| Title
| |
| adms:identifier
| |
| http://linked.open...y/drugbank/patent
| |
| http://linked.open...outeOfElimination
| - Approximately 70% of the doses were excreted in urine and feces within 2 days after treatment. (PMID 5312397) (en)
|
| http://linked.open.../drugbank/synonym
| - Dimetacrine (en)
- Istonil (en)
- Istonyl (en)
- Linostil (en)
- Miroistonil (en)
- 3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine (en)
|
| http://linked.open...drugbank/toxicity
| - Dimetacrine may induce severe cardiac toxicity in overdose. This property is unique among the tricyclic antidepressants. (en)
|
| http://linked.open...umeOfDistribution
| - The highest concentrations of dimetacrine were found at 1 hour after administration but at 3 hours in brain, heart, lung, liver, spleen, kidney, skeletal muscle and adipose tissue of testes. (Carried out in mice, PMID 5312397). (en)
|
| http://linked.open...ogy/drugbank/salt
| |
| http://linked.open...ynthesisReference
| - # http://worldwide.espacenet.com/publicationDetails/biblio?CC=GB&NR=933875&KC=&FT=E&locale=en_EP (en)
|
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
| |
| http://linked.open.../Water-Solubility
| |
| http://linked.open...ogy/drugbank/logP
| |
| http://linked.open...ogy/drugbank/logS
| |
| http://linked.open...l/drug/hasATCCode
| |
| http://linked.open...nd-Acceptor-Count
| |
| http://linked.open...-Bond-Donor-Count
| |
| http://linked.open...drugbank/InChIKey
| |
| http://linked.open...urface-Area--PSA-
| |
| http://linked.open...nk/Polarizability
| |
| http://linked.open...bank/Refractivity
| |
| http://linked.open...atable-Bond-Count
| |
| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...k/Bioavailability
| |
| http://linked.open...bank/Ghose-Filter
| |
| http://linked.open...nk/MDDR-Like-Rule
| |
| http://linked.open...ank/Melting-Point
| |
| http://linked.open...k/Number-of-Rings
| |
| http://linked.open...siological-Charge
| |
| http://linked.open...bank/Rule-of-Five
| |
| http://linked.open...tional-IUPAC-Name
| |
| http://linked.open...-strongest-basic-
| |
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