| Attributes | Values |
|---|
| rdf:type
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| http://linked.open...gbank/description
| - A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic. [PubChem] (en)
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| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...generalReferences
| - # Rhodes MC, Seidler FJ, Abdel-Rahman A, Tate CA, Nyska A, Rincavage HL, Slotkin TA: Terbutaline is a developmental neurotoxicant: effects on neuroproteins and morphology in cerebellum, hippocampus, and somatosensory cortex. J Pharmacol Exp Ther. 2004 Feb;308(2):529-37. Epub 2003 Nov 10. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14610225 # Hochhaus G, Mollmann H: Pharmacokinetic/pharmacodynamic characteristics of the beta-2-agonists terbutaline, salbutamol and fenoterol. Int J Clin Pharmacol Ther Toxicol. 1992 Sep;30(9):342-62. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1358833 # Haahtela T, Jarvinen M, Kava T, Kiviranta K, Koskinen S, Lehtonen K, Nikander K, Persson T, Reinikainen K, Selroos O, et al.: Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma. N Engl J Med. 1991 Aug 8;325(6):388-92. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2062329 (en)
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| http://linked.open...gy/drugbank/group
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| http://linked.open...drugbank/halfLife
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| http://linked.open...ugbank/indication
| - For the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible, obstructive airway disease, as well as symptomatic management of reversible bronchospasm associated with bronchitis and emphysema. Also used acute IV and sub-Q therapy in selected women to inhibit uterine contractions in preterm labor (tocolysis) and prolong gestation when beneficial. (en)
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| http://linked.open...bank/manufacturer
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| sameAs
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| Title
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| adms:identifier
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| http://linked.open...mechanismOfAction
| - The pharmacologic effects of terbutaline are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. (en)
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| http://linked.open...drugbank/packager
| |
| http://linked.open...outeOfElimination
| - About 90% of the drug was excreted in the urine at 96 hours after subcutaneous administration, with about 60% of this being unchanged drug. It appears that the sulfate conjugate is a major metabolite of terbutaline and urinary excretion is the primary route of elimination (en)
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| http://linked.open.../drugbank/synonym
| - Terbutalin (en)
- Terbutalina (en)
- Terbutaline (sulfate de) (en)
- Terbutalini sulfas (en)
- Terbutalinsulfat (en)
- Terbutalinum (en)
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| http://linked.open...drugbank/toxicity
| - Terbutaline Sulfate: Oral LD<sub>50</sub>(rat) = 8.7 g/kg; Oral LD<sub>50</sub>(mouse) = 205 mg/kg; Oral LD<sub>50</sub>(dog) = 1.5 g/kg; IP LD<sub>50</sub>(rat)= 220 mg/kg ; IP LD<sub>50</sub>(mouse) = 130 mg/kg; Oral LD<sub>50</sub>(rabbit) = >8 g/kg; IV LD<sub>50</sub>(mouse) = 36 mg/kg; IV LD<sub>50</sub>(dog) = 116 mg/kg; IV LD<sub>50</sub>(rabbit) = 110 mg/kg (en)
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| http://linked.open.../drug/hasAHFSCode
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| http://linked.open.../drugbank/mixture
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| http://linked.open...ogy/drugbank/salt
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| http://linked.open...ynthesisReference
| - Alison B. Lukacsko, Joseph J. Piala, "Effect of a combination of a terbutaline, diphenhydramine and ranitidine composition on gastrointestinal injury produced by nonsteroidal anti-inflammatory compositions." U.S. Patent US5260333, issued December, 1983. (en)
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| foaf:page
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| http://linked.open...ugbank/IUPAC-Name
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| http://linked.open...gy/drugbank/InChI
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| http://linked.open...Molecular-Formula
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| http://linked.open.../Molecular-Weight
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| http://linked.open...noisotopic-Weight
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| http://linked.open...y/drugbank/SMILES
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| http://linked.open.../Water-Solubility
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| http://linked.open...ogy/drugbank/logP
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| http://linked.open...ogy/drugbank/logS
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| http://linked.open...l/drug/hasATCCode
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| http://linked.open...nd-Acceptor-Count
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| http://linked.open...-Bond-Donor-Count
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| http://linked.open...drugbank/InChIKey
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| http://linked.open...urface-Area--PSA-
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| http://linked.open...nk/Polarizability
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| http://linked.open...bank/Refractivity
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| http://linked.open...atable-Bond-Count
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| http://linked.open...ugbank/absorption
| - Approximately 30-50% if administered orally and well absorbed subcutaneously. (en)
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