About: Hexachlorophene

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797) (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B591E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B591F-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en) withdrawn (en)
http://linked.open...ugbank/indication	For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful. (en)
http://linked.open...bank/manufacturer	Prepackage Specialists Prepak Systems Inc. Remedy Repack Sandoz Bayer pharmaceuticals corp Teva Pharmaceutical Industries Ltd. UDL Laboratories Merrell Pharmaceuticals Inc. Becton dickinson and co App pharmaceuticals llc Davis and geck div american cyanamid co 3m co
sameAs	Hexachlorophene
Title	Hexachlorophene (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00756/identifier/chemspider/3472 http://linked.opendata.cz/resource/drugbank/drug/DB00756/identifier/drugbank/DB00756 http://linked.opendata.cz/resource/drugbank/drug/DB00756/identifier/kegg-compound/C08039 http://linked.opendata.cz/resource/drugbank/drug/DB00756/identifier/kegg-drug/D00859 http://linked.opendata.cz/resource/drugbank/drug/DB00756/identifier/national-drug-code-directory/0024-1535-02 http://linked.opendata.cz/resource/drugbank/drug/DB00756/identifier/pharmgkb/PA449871 http://linked.opendata.cz/resource/drugbank/drug/DB00756/identifier/pubchem-compound/3598 http://linked.opendata.cz/resource/drugbank/drug/DB00756/identifier/pubchem-substance/46505858 http://linked.opendata.cz/resource/drugbank/drug/DB00756/identifier/wikipedia/Hexachlorophene
http://linked.open...mechanismOfAction	The primary mechanism of action of hexachlorophene, based on studies with <i>Bacillus megatherium</i>, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration. (en)
http://linked.open...drugbank/packager	Bayer Healthcare Mylan Novex Pharma Pharmaceutical Association Physicians Total Care Inc.
http://linked.open.../drugbank/synonym	Acigena (en) Almederm (en) Distodin (en) Exofene (en) Gamophen (en) Gamophene (en) Hexabalm (en) Hexafen (en) Hexascrub (en) Hexide (en) Nabac (en) Phisodan (en) Septisol (en) Septofen (en) Steral (en) Steraskin (en) Surofene (en) Tersaseptic (en) Turgex (en) 2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane (en) 2,2'-Methanediylbis(3,4,6-trichlorophenol) (en) Armohex (en) Bis(2-hydroxy-3,5,6-trichlorophenyl)methane (en) Bis(3,5,6-trichloro-2-hydroxyphenyl)methane (en) Esaclorofene (en) Germa-medica (en) Hexa-germ (en) Hexachlorophenum (en) Hexaclorofeno (en) Phiso-scrub (en) Septi-soft (en) Solu-heks (en) Soy-dome (en) Staphene O (en) Ster-zac (en) Surgi-cen (en) Surgi-cin (en) 2,2'-Dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane (en) 2,2',3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane (en)
http://linked.open...drugbank/toxicity	Oral, rat LD<sub>50</sub>: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/84-04-92
http://linked.open...nk/proteinBinding	92% (en)
http://linked.open...ynthesisReference	U.S. Patent 2,250,480 U.S. Patent 2,435,593 U.S. Patent 2,812,365 (en)
foaf:page	http://www.drugs.com/cdi/hexachlorophene.html http://www.rxlist.com/cgi/generic2/hexchlorph.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5924-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B592A-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5929-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5926-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5927-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B5928-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B5922-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B593A-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B5920-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B5923-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B593D-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B5921-363D-11E5-9242-09173F13E4C5
http://linked.open...logy/drugbank/pKa	http://linked.opendata.cz/resource/drugbank/property/271B593E-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Hexachlorophene
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5930-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5931-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B592B-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B592C-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B592E-363D-11E5-9242-09173F13E4C5

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