| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. [PubChem] (en)
|
| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...gy/drugbank/group
| |
| http://linked.open...drugbank/halfLife
| |
| http://linked.open...ugbank/indication
| - For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by <i>Trichophyton</i> or <i>Microsporum</i> fungi. (en)
|
| http://linked.open...bank/manufacturer
| |
| sameAs
| |
| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. It also binds to and interferes with the function of spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. It binds to keratin in human cells, then once it reaches the fungal site of action, it binds to fungal microtubes thus altering the fungal process of mitosis. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open.../drugbank/synonym
| - Griseofulvin (en)
- Amudane (en)
- Curling factor (en)
- Fulcin (en)
- Fulvicin (en)
- Grifulvin (en)
- Grisactin (en)
- Grisovin (en)
- Grysio (en)
- Lamoryl (en)
- Likuden (en)
- Poncyl (en)
- Spirofulvin (en)
- Sporostatin (en)
- (+)-griseofulvin (en)
- Griseofulvina (en)
- Griseofulvine (en)
- Griseofulvinum (en)
|
| http://linked.open...drugbank/toxicity
| - Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions (en)
|
| http://linked.open...k/foodInteraction
| - Avoid alcohol. (en)
- Take this medication with a high fat meal, fatty foods increase bioavailability. (en)
|
| http://linked.open...ynthesisReference
| - Gary Liversidge, "Methods of making and using novel griseofulvin compositions." U.S. Patent US20070098805, issued May 03, 2007. (en)
|
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
| |
| http://linked.open.../Water-Solubility
| |
| http://linked.open...ogy/drugbank/logP
| |
| http://linked.open...ogy/drugbank/logS
| |
| http://linked.open...l/drug/hasATCCode
| |
| http://linked.open...nd-Acceptor-Count
| |
| http://linked.open...-Bond-Donor-Count
| |
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