About: Nitroprusside

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency. [Wikipedia] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B54DB-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54DC-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Approximately 2 minutes (en)
http://linked.open...ugbank/indication	For immediate reduction of blood pressure of patients in hypertensive crises, reduce bleeding during surgery, and for the treatment of acute congestive heart failure (en)
http://linked.open...bank/manufacturer	Hoffmann la roche inc Abbott laboratories Abbott laboratories pharmaceutical products div Epic pharma llc Abraxis pharmaceutical products Baxter healthcare corp anesthesia and critical care Mylan pharmaceuticals inc
sameAs	Nitroprusside
Title	Nitroprusside (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00325/identifier/chebi/7596 http://linked.opendata.cz/resource/drugbank/drug/DB00325/identifier/chemspider/10137785 http://linked.opendata.cz/resource/drugbank/drug/DB00325/identifier/drugbank/DB00325 http://linked.opendata.cz/resource/drugbank/drug/DB00325/identifier/kegg-compound/C07269 http://linked.opendata.cz/resource/drugbank/drug/DB00325/identifier/national-drug-code-directory/0409-3024-01 http://linked.opendata.cz/resource/drugbank/drug/DB00325/identifier/pubchem-compound/11963622 http://linked.opendata.cz/resource/drugbank/drug/DB00325/identifier/pubchem-substance/46508965 http://linked.opendata.cz/resource/drugbank/drug/DB00325/identifier/pharmgkb/PA451406 http://linked.opendata.cz/resource/drugbank/drug/DB00325/identifier/wikipedia/Nitroprusside
http://linked.open...mechanismOfAction	One molecule of sodium nitroprusside is metabolized by combination with hemoglobin to produce one molecule of cyanmethemoglobin and four CN- ions; methemoglobin, obtained from hemoglobin, can sequester cyanide as cyanmethemoglobin; thiosulfate reacts with cyanide to produce thiocyanate; thiocyanate is eliminated in the urine; cyanide not otherwise removed binds to cytochromes. Cyanide ion is normally found in serum; it is derived from dietary substrates and from tobacco smoke. Cyanide binds avidly (but reversibly) to ferric ion (Fe+++), most body stores of which are found in erythrocyte methemoglobin (metHgb) and in mitochondrial cytochromes. When CN is infused or generated within the bloodstream, essentially all of it is bound to methemoglobin until intraerythrocytic methemoglobin has been saturated. Once activated to NO, it activates guanylate cyclase in vascular smooth muscle and increases intracellular production of cGMP. cGMP stimulates calcium movement from the cytoplasm to the endoplasmic reticulum and reduces calcium available to bind with calmodulin. This eventually leads to vascular smooth muscle relaxation and vessel dilatation. (en)
http://linked.open...drugbank/packager	Baxter International Inc. Hospira Inc. Physicians Total Care Inc. Teva Pharmaceutical Industries Ltd.
http://linked.open...outeOfElimination	One molecule of sodium nitroprusside is metabolized by combination with hemoglobin to produce one molecule of cyanmethemoglobin and four CN¯ ions, thiosulfate reacts with cyanide to produce thiocyanate, thiocyanate is eliminated in the urine. (en)
http://linked.open.../drugbank/synonym	Nitroferricyanide (en) [Fe(CN)5(NO)](2-) (en)
http://linked.open...drugbank/toxicity	Overdosage of nitroprusside can be manifested as excessive hypotension or cyanide toxicity or as thiocyanate toxicity. The acute intravenous mean lethal doses (LD<sub>50</sub>) of nitroprusside in rabbits, dogs, mice, and rats are 2.8, 5.0, 8.4, and 11.2 mg/kg, respectively. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/24-08-20
http://linked.open.../drugbank/mixture	Cora-Bosan B43
http://linked.open...ogy/drugbank/salt	(en)
foaf:page	http://www.drugs.com/mtm/nitroprusside.html http://www.rxlist.com/cgi/generic3/nitroprusside.htm
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http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B54E3-363D-11E5-9242-09173F13E4C5
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http://linked.open...l/drug/hasATCCode	Nitroprusside
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	15078-28-1 (en)
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B54EF-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B54F1-363D-11E5-9242-09173F13E4C5
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http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B54EC-363D-11E5-9242-09173F13E4C5

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