About: L-Methionine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type
http://linked.open...gbank/description
  • A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals. [PubChem] (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • nutraceutical (en)
http://linked.open...ugbank/indication
  • Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate. (en)
sameAs
Title
  • L-Methionine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • The mechanism of the possible anti-hepatotoxic activity of L-methionine is not entirely clear. It is thought that metabolism of high doses of acetaminophen in the liver lead to decreased levels of hepatic glutathione and increased oxidative stress. L-methionine is a precursor to L-cysteine. L-cysteine itself may have antioxidant activity. L-cysteine is also a precursor to the antioxidant glutathione. Antioxidant activity of L-methionine and metabolites of L-methionine appear to account for its possible anti-hepatotoxic activity. Recent research suggests that methionine itself has free-radical scavenging activity by virtue of its sulfur, as well as its chelating ability. (en)
http://linked.open...drugbank/packager
http://linked.open.../drugbank/synonym
  • Methionine (en)
  • L-Methionine (en)
  • (S)-2-amino-4-(methylthio)butanoic acid (en)
  • (S)-2-amino-4-(methylthio)butyric acid (en)
  • (S)-methionine (en)
  • L-(-)-Methionine (en)
  • L-a-Amino-g-methylthiobutyric acid (en)
  • M (en)
  • (2S)-2-amino-4-(Methylsulfanyl)butanoic acid (en)
  • L-Methionin (en)
  • L-alpha-amino-gamma-Methylmercaptobutyric acid (en)
  • L-α-amino-γ-methylmercaptobutyric acid (en)
  • Met (en)
http://linked.open...drugbank/toxicity
  • Doses of L-methionine of up to 250 mg daily are generally well tolerated. Higher doses may cause nausea, vomiting and headache. Healthy adults taking 8 grams of L-methionine daily for four days were found to have reduced serum folate levels and leucocytosis. Healthy adults taking 13.9 grams of L-methionine daily for five days were found to have changes in serum pH and potassium and increased urinary calcium excretion. Schizophrenic patients given 10 to 20 grams of L-methionine daily for two weeks developed functional psychoses. Single doses of 8 grams precipitated encephalopathy in patients with cirrhosis. (en)
http://linked.open...k/foodInteraction
  • Take with food. (en)
http://linked.open...ynthesisReference
  • Clyde Eugene Stauffer, "Process for producing N-acyl-L-methionine." U.S. Patent US3963573, issued June, 1950. (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...logy/drugbank/pKa
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Absorbed from the lumen of the small intestine into the enterocytes by an active transport process. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 63-68-3 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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