About: Insulin, porcine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Insulin isolated from pig pancreas. Composed of alpha and beta chains, processed from pro-insulin. Forms a hexameric structure. (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the treatment of type I and II diabetes mellitus. (en)
http://linked.open...bank/manufacturer	AstraZeneca Inc. Baxter International Inc.
sameAs	Insulin, porcine
Title	Insulin, porcine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00071/identifier/drugbank/DB00071 http://linked.opendata.cz/resource/drugbank/drug/DB00071/identifier/genbank/AY137503 http://linked.opendata.cz/resource/drugbank/drug/DB00071/identifier/uniprotkb/Q8HXV2 http://linked.opendata.cz/resource/drugbank/drug/DB00071/identifier/pharmgkb/PA164781053
http://linked.open...mechanismOfAction	Insulin binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor is able to autophosphorylate and phosphorylate numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. These activated proteins, in turn, lead to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC) which play a critical role in metabolism. (en)
http://linked.open...ynthesisReference	Bruce H. Frank, "Process for producing an insulin precursor." U.S. Patent US4430266, issued November, 1974. (en)
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B435D-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B435C-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B4359-363D-11E5-9242-09173F13E4C5
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	9004-14-2 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B435A-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B435B-363D-11E5-9242-09173F13E4C5

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