About: NG-nitro-L-arginine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • NG-nitro-L-arginine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • NG-nitro-L-arginine
UMLS_CUI
  • C0068821
PDQ_Open_Trial_Search_ID
  • 697835
PDQ_Closed_Trial_Search_ID
  • 697835
CHEBI_ID
  • CHEBI:27960
FULL_SYN
  • NOLAABNCI
  • L-NNAABNCI
  • NG-nitro-L-argininePTNCI
DEFINITION
  • An amino acid derivative and nitric oxide synthase (NOS) inhibitor with potential antineoplastic and antiangiogenic activities. Upon administration, NG-nitro-L-arginine inhibits the enzyme nitric oxide synthase, thereby preventing the formation of nitric oxide (NO). By preventing NO generation, the vasodilatory effects of NO are abrogated leading to vasoconstriction, reduction in vascular permeability and an inhibition of angiogenesis. As blood flow to tumors is restricted, this may result in an inhibition of tumor cell proliferation. NO plays an important role in tumor blood flow and stimulation of angiogenesis, tumor progression, survival, migration and invasiveness.NCI
code
  • C96232
sameAs
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