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AttributesValues
rdf:type
rdfs:label
  • Efatutazone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Efatutazone
UMLS_CUI
  • C2827204
CAS_Registry
  • 223132-37-4
FDA_UNII_Code
  • M17ILL71MC
Contributing_Source
  • FDA
Chemical_Formula
  • C27H26N4O4S
FULL_SYN
  • EfatutazonePTNCI
  • InolitazoneSYNCI
  • Rac-5-((4-((6-(4-Amino-3,5-Dimethylphenoxy)-1-Methyl-1H-Benzimidazol-2-yl)Methoxy)Phenyl)Methyl)-1,3-Thiazolidine-2,4-DioneSNNCI
  • 2,4-Thiazolidinedione, 5-((4-((6-(4-Amino-3,5-Dimethylphenoxy)-1-Methyl-1H-Benzimidazol-2-yl)Methoxy)Phenyl)Methyl)-SNNCI
  • EFATUTAZONEPTFDAM17ILL71MC
DEFINITION
  • An orally bioavailable thiazolidinedione and an agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity. Efatutazone binds to and activates PPAR-gamma thus inducing cell differentiation and apoptosis, leading to a reduction in cellular proliferation. PPAR-gamma is a nuclear hormone receptor and a ligand-activated transcription factor that controls the expression of genes involved in macromolecule metabolism and cell differentiation, specifically adipocyte differentiation.NCI
code
  • C83819
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