About: Cidofovir Anhydrous     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cidofovir Anhydrous
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cidofovir Anhydrous
UMLS_CUI
  • C2699210
CAS_Registry
  • 113852-37-2
FDA_UNII_Code
  • 768M1V522C
Contributing_Source
  • FDA
Chemical_Formula
  • C8H14N3O6P
Legacy_Concept_Name
  • Cidofovir_Anhydrous
CHEBI_ID
  • CHEBI:3696
FULL_SYN
  • Cidofovir AnhydrousPTNCI
  • CIDOFOVIR ANHYDROUSPTFDA768M1V522C
DEFINITION
  • An anhydrous form of cidofovir, a synthetic, acyclic monophosphate nucleotide analog of deoxycytidine with antiviral activity, mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses.NCI
code
  • C77925
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