About: Liposomal MnSOD Plasmid     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Liposomal MnSOD Plasmid
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Liposomal MnSOD Plasmid
NCI_META_CUI
  • CL383936
PDQ_Open_Trial_Search_ID
  • 589811
PDQ_Closed_Trial_Search_ID
  • 589811
Legacy_Concept_Name
  • Liposomal_MnSOD_Plasmid
FULL_SYN
  • MnSOD Plasmid LiposomesSYNCI
  • Liposomal MnSOD PlasmidPTNCI
  • MnSOD-PLABNCI
DEFINITION
  • A plasmid DNA encoding human manganese superoxide dismutase (MnSOD) and liposomally encapsulated with potential chemoprotective activity. When administered orally and localizing in the esophagus, MnSOD-plasmid liposomes express MnSOD, which scavenges reactive oxygen species (ROS); MnSOD scavenging of ROS may result in a reduction in ROS-mediated lipid peroxidation, apoptosis, and micro-ulceration in the epithelial lining of the esophagus.NCI
code
  • C74054
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