About: Indomethacin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Indomethacin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Indomethacin
NSC_Code
  • 77541
UMLS_CUI
  • C0021246
CAS_Registry
  • 53-86-1
Accepted_Therapeutic_Use_For
  • Dysmennorhea; Inflammatory disorders; Pain
In_Clinical_Trial_For
  • Advanced colorectal cancer
FDA_UNII_Code
  • XXE1CET956
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that reduces pain, fever, swelling, and redness. It is also being used to reduce tumor-induced suppression of the immune system and to increase the effectiveness of anticancer drugs. It is a type of nonsteroidal anti-inflammatory drug (NSAID).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39489
PDQ_Closed_Trial_Search_ID
  • 39489
Chemical_Formula
  • C19H16ClNO4
Legacy_Concept_Name
  • Indomethacin
CHEBI_ID
  • CHEBI:49662
FULL_SYN
  • IndometacinSYNCI
  • IndomethacinPTNCI
  • 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acidSNNCI
  • indomethacinPTNCI-GLOSSCDR0000045223
  • IndocinSYDTPNSC0077541
  • IndomethacinPTDCP00069
  • IndocinBRNCI
  • INDOMETHACINPTFDAXXE1CET956
DEFINITION
  • A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04)NCI
code
  • C576
sameAs
http://linked.open...y/mesh/hasConcept
is someValuesFrom of
is Has_Free_Acid_Or_Base_Form of
is sameAs of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 24 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software