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AttributesValues
rdf:type
rdfs:label
  • Multidrug Resistance Inhibition
rdfs:subClassOf
Semantic_Type
  • Physiologic Function
Preferred_Name
  • Multidrug Resistance Inhibition
UMLS_CUI
  • C1513739
Legacy_Concept_Name
  • Multidrug_Resistance_Inhibition
FULL_SYN
  • Multidrug Resistance InhibitionPTNCI
DEFINITION
  • Multidrug Resistance Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in processes that increase the ability of cancer cells to counteract, defeat, or withstand the effects of multiple chemotherapeutic agents. Mechanisms involve decreased expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, increased topoisomerase II activity, and changes in various cellular proteins. Inhibition results in increased transport of drug into, or decreased transport out of, cells and increased effectiveness of chemotherapeutic agents.NCI
code
  • C40818
is rdfs:subClassOf of
is someValuesFrom of
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