About: Immunoglobulin Heavy Locus

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Immunoglobulin Heavy Locus
equivalentClass	nodeID://b633904
GenBank_Accession_Number	NG_001019
Semantic_Type	Gene or Genome
Preferred_Name	Immunoglobulin Heavy Locus
UMLS_CUI	C0017351
EntrezGene_ID	3492
Legacy_Concept_Name	Immunoglobulin_Heavy_Locus
HGNC_ID	HGNC:5477
FULL_SYN	Immunoglobulin Heavy Chain LocusSYNCI Immunoglobulin Heavy LocusSYNCITCGA Immunoglobulin Heavy GeneSYNCI IGHSYNCI Immunoglobulin Heavy LocusPTNCI IGH@SYNCI Immunoglobulin Heavy Chain GeneSYNCI
Gene_Encodes_Product	Immunoglobulin Heavy Chain
DEFINITION	This region represents the germline organization of the immunoglobulin heavy chain locus. The locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)NCI
code	C26422
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0009096
is someValuesFrom of	nodeID://b649466 nodeID://b649505 nodeID://b660806 nodeID://b682320 nodeID://b726820 nodeID://b726897

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