About: Monoclonal Antibody Mono-dgA-RFB4     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Monoclonal Antibody Mono-dgA-RFB4
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Monoclonal Antibody Mono-dgA-RFB4
UMLS_CUI
  • C0935906
In_Clinical_Trial_For
  • B-cell Lymphoma.
PDQ_Open_Trial_Search_ID
  • 38178
PDQ_Closed_Trial_Search_ID
  • 38178
Legacy_Concept_Name
  • Monoclonal_Antibody_Mono-dgA-RFB4
FULL_SYN
  • Monoclonal Antibody Mono-dgA-RFB4PTNCI
  • MONO dgA RFB4ABNCI
DEFINITION
  • An immunotoxin of monoclonal antibody (MoAb) RFB4 covalently linked to a single deglycosylated ricin toxin A-chain (dgA), originated from castor beans. MoAb RFB4 recognizes CD22 antigen, a B-cell adhesion protein expressed on malignant cells in about 70 percent of non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Ricin toxin A-chain, a potent protein synthesis inhibitor, was deglycosylated and was used in this immunoconjugate to avoid hepatic entrapment. This agent limits specific cytotoxicity of ricin toxin to CD22-positive malignant cells.NCI
code
  • C2611
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