About: Estrogen Receptor Family     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Estrogen Receptor Family
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
Preferred_Name
  • Estrogen Receptor Family
UMLS_CUI
  • C0034804
Legacy_Concept_Name
  • Estrogen_Receptor
FULL_SYN
  • Estrogen Receptor Family ProteinSYNCI
  • Estrogen Receptor FamilyPTNCI
  • ERSYNCI
  • Nuclear Receptor Subfamily 3 Group ASYNCI
  • NR3ASYNCI
  • Estrogen ReceptorSYNCI
  • Estradiol ReceptorSYNCI
  • ER FamilySYNCI
DEFINITION
  • Widely expressed human Estrogen Receptors (NR3 Family) are cytoplasmic hormone-activated receptors that act as nuclear transcription factors composed of an N-terminal transcription activation/modulation domain, a DNA-binding domain, and a C-terminal steroid-binding domain. Binding to DNA as a homo- or heterodimer, ESR interacts with NCOA3, NCOA5, and NCOA6 coactivators. Hormone-ESR complexes appear to recognize discrete upstream target ERE DNA sequences to regulate gene expression, cell proliferation, and differentiation. DNA-binding is lost in the absence of ligand. (NCI)NCI
code
  • C17069
sameAs
http://linked.open...y/mesh/hasConcept
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is Has_Target of
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