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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Liposomal NDDP
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Liposomal NDDP
UMLS_CUI
  • C0125061
CAS_Registry
  • 114488-24-3
PDQ_Open_Trial_Search_ID
  • 43010
PDQ_Closed_Trial_Search_ID
  • 43010
Legacy_Concept_Name
  • Liposomal-Cisplatin_Analogue
FULL_SYN
  • Liposomal Neodecanoic Acid Platinum ComplexSYNCI
  • Liposomal-Entrapped Cis-Bis-Neodecanoate-trans-R,R-1,2-Diaminocyclohexane Platinum (II)SNNCI
  • Liposomal NDDPPTNCI
  • L-NDDPABNCI
  • Liposomal-Cisplatin AnalogueSYNCI
  • AroplatinBRNCI
DEFINITION
  • A synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity. After displacement of the 2 long-chain aliphatic leaving groups (neodecanoic acid), platinum diaminocyclohexane (DACH) complexes become highly reactive and alkylate macromolecules, forming both inter- and intra-stranded DNA cross-linkings and inhibiting DNA synthesis, which results in tumor cell cytotoxicity. Because DNA mismatch-repair (MMR) complexes do not recognize DACH-platinum adducts, DNA repair mechanisms are inhibited, overcoming limitations observed with other platinum-based agents. In addition, the liposomal encapsulation improves the bioavailability of NDDP and reduces its toxicity profile.NCI
code
  • C1383
http://linked.open...y/mesh/hasConcept
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