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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Nuclear Lamina
rdfs:subClassOf
Semantic_Type
  • Cell Component
Preferred_Name
  • Nuclear Lamina
UMLS_CUI
  • C1136039
Legacy_Concept_Name
  • Nuclear_Lamina
FULL_SYN
  • Nuclear LaminaPTNCI
DEFINITION
  • The nuclear lamina is a proteinaceous filamentous meshwork of lamin proteins interacting with integral proteins of the inner nuclear membrane, including emerin, and is thought to play a role in nuclear stability, chromatin structure, and gene expression. Lamins are highly conserved in evolution and members of the intermediate filament protein family. Mammalian lamins are classified into two major types, A and B, with two subspecies of each: lamins A and C for the A type and B1 and B2 for the B type. Lamins A and C arise from one gene by alternative splicing. Pre-lamin A contains a carboxyl CAAX box that can be modified by farnesylation. During mitosis, the lamina meshwork is reversibly disassembled in parallel with phosphorylation of the lamins.NCI
code
  • C13809
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