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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Oprelvekin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • Oprelvekin
UMLS_CUI
  • C0537670
CAS_Registry
  • 145941-26-0
Accepted_Therapeutic_Use_For
  • Chemotherapy-related thrombocytopenia
In_Clinical_Trial_For
  • Non-Hodgkins lymphoma; Crohns disease
FDA_UNII_Code
  • HM5641GA6F
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to increase the number of blood cells, especially platelets, in some cancer patients receiving chemotherapy. Neumega is a form of interleukin-11 (a cytokine normally made by support cells in the bone marrow) that is made in the laboratory. It is a type of biological response modifier.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42365
PDQ_Closed_Trial_Search_ID
  • 42365
Legacy_Concept_Name
  • Therapeutic_Interleukin-11
FULL_SYN
  • Interleukin 11SYNCI
  • Adipogenesis Inhibitory FactorSYNCI
  • Interleukin-11-RecombinantSYNCI
  • NeumegaBRNCI
  • OprelvekinPTNCI
  • oprelvekinPTNCI-GLOSSCDR0000520411
  • recombinant human interleukin-11PTNCI-GLOSSCDR0000580268
  • Interleukin-11SYNCI
  • Recombinant Interleukin-11SYNCI
  • IL-11ABNCI
  • rhIL-11PTNCI-GLOSSCDR0000580275
  • NeumegaPTNCI-GLOSSCDR0000580234
  • rhIL-11ABNCI
  • OPRELVEKINPTFDAHM5641GA6F
  • Recombinant Human Interleukin-11SYNCI
DEFINITION
  • A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin 11 (IL-11). Secreted by bone marrow stromal cells and a number of mesenchymal cells, IL-11 binds to and activates its cell-surface receptor, promoting primary and secondary immune responses, modulating antigen-specific antibody reactions, and preventing apoptotic cell death. This agent also stimulates the T-cell-dependent development of IgG-secreting B-cells in spleen cell cultures and may be an important regulator of megakaryocytopoiesis. (NCI04)NCI
code
  • C1303
sameAs
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