About: Recombinant Human Hsp110-gp100 Chaperone Complex Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Human Hsp110-gp100 Chaperone Complex Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Human Hsp110-gp100 Chaperone Complex Vaccine
NCI_META_CUI
  • CL438310
PDQ_Open_Trial_Search_ID
  • 742760
PDQ_Closed_Trial_Search_ID
  • 742760
FULL_SYN
  • Recombinant Human Hsp110-gp100 Chaperone Complex VaccinePTNCI
DEFINITION
  • A recombinant chaperone-peptide complex-based vaccine composed of a complex between heat shock protein hsp110 and the human melanoma-associated antigen gp100, with potential antineoplastic activity. Upon vaccination, recombinant hsp110-gp100 chaperone complex activates the immune system to exert a cytotoxic T cell immune response and antigen-specific interferon-gamma production against gp100-overexpressing cancer cells. Gp100, is overexpressed in a variety of cancer cell types. Hsp110, binds to and chaperones full-length proteins during heat shock; as an immunoadjuvant it is able to enhance an immune response against antigen(s) and stimulate T-lymphocyte activation.NCI
code
  • C103830
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