About: PLED-based MnSOD Mimetic     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • PLED-based MnSOD Mimetic
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • PLED-based MnSOD Mimetic
NCI_META_CUI
  • CL437004
PDQ_Open_Trial_Search_ID
  • 735792
PDQ_Closed_Trial_Search_ID
  • 735792
FULL_SYN
  • PLED-based MnSOD MimeticPTNCI
  • PP-095CNNCI
  • PLEDOxFBNCI
DEFINITION
  • A derivative of pyridoxyl ethyldiamine (PLED) and mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD), with antioxidant, metal chelating and potential chemoprotective activities. Upon administration, PLED-based MnSOD mimetic mimics MnSOD and scavenges oxygen free radicals such as superoxide anion, hydrogen peroxide, and hydroxyl radical, thereby preventing oxygen free radical damage to macromolecules such as DNA and minimizing oxygen free radical-related chemotoxicity in normal tissues. In addition, this agent is able to strongly bind to iron.NCI
code
  • C102747
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