About: Canfosfamide     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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  • Canfosfamide is an active agent in chemotherapy-resistant ovarian cancer. (en)
http://linked.open...generalReferences
  • # Rosen LS, Brown J, Laxa B, Boulos L, Reiswig L, Henner WD, Lum RT, Schow SR, Maack CA, Keck JG, Mascavage JC, Dombroski JA, Gomez RF, Brown GL: Phase I study of TLK286 (glutathione S-transferase P1-1 activated glutathione analogue) in advanced refractory solid malignancies. Clin Cancer Res. 2003 May;9(5):1628-38. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12738715 # Rosen LS, Laxa B, Boulos L, Wiggins L, Keck JG, Jameson AJ, Parra R, Patel K, Brown GL: Phase 1 study of TLK286 (Telcyta) administered weekly in advanced malignancies. Clin Cancer Res. 2004 Jun 1;10(11):3689-98. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15173075 # Kavanagh JJ, Gershenson DM, Choi H, Lewis L, Patel K, Brown GL, Garcia A, Spriggs DR: Multi-institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer. Int J Gynecol Cancer. 2005 Jul-Aug;15(4):593-600. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16014111 # Manufacturer Site "Link":http://www.telik.com/pipe_telcyta.html (en)
http://linked.open...gy/drugbank/group
  • investigational (en)
http://linked.open...drugbank/halfLife
  • 18 min (en)
http://linked.open...ugbank/indication
  • Intended for the treatment of various forms of cancer. (en)
sameAs
Title
  • Canfosfamide (en)
adms:identifier
http://linked.open...mechanismOfAction
  • S-transferase P1-1 (GST P1-1) is an enzyme overexpressed in many human cancer cells. High levels of GST P1-1 are associated with a poor prognosis and resistance to certain chemotherapeutics. The activation of canfosfamide occurs when GST P1-1 splits canfosfamide into two active fragments: a glutathione analog fragment and an active cytotoxic fragment. The cytotoxic fragment reacts with important cell components, including RNA, DNA and proteins, leading to cell death. The glutathione analog fragment of canfosfamide may remain bound to GST P1-1, which may limit the ability of GST P1-1 to inactivate other cancer drugs. (en)
http://linked.open...drugbank/toxicity
  • Canfosfamide-related toxicities included grade 1-2 nausea, vomiting, fatigue, transient microscopic hematuria, and anemia. (en)
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...ugbank/IUPAC-Name
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http://linked.open...bank/Refractivity
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http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 439943-59-6 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
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http://linked.open...-strongest-basic-
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