About: Amdinocillin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type
http://linked.open...gbank/description
  • Amidinopenicillanic acid derivative with broad spectrum antibacterial action. It is poorly absorbed if given orally and is used in urinary infections and typhus. Amdinocillin is not available in the United States. (en)
http://linked.open...generalReferences
  • # Neu HC: Penicillin-binding proteins and role of amdinocillin in causing bacterial cell death. Am J Med. 1983 Aug 29;75(2A):9-20. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6311012 (en)
http://linked.open...gy/drugbank/group
  • withdrawn (en)
http://linked.open...drugbank/halfLife
  • Approximately 1 hour in patients with normal renal function. Increases to 3 to 6 hours in anephric patients. (en)
http://linked.open...ugbank/indication
  • Used in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species. Used mainly against Gram negative organisms. (en)
sameAs
Title
  • Amdinocillin (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Amdinocillin is a stong and specific antagonist of Penicillin Binding Protein-2 (PBP 2). It is active against gram negative bacteria, preventing cell wall synthesis by inhibiting the activity of PBP2. PBP2 is a peptidoglycan elongation initiating enzyme. Peptidoglycan is a polymer of sugars and amino acids that is the main component of bacterial cell walls. (en)
http://linked.open.../drugbank/synonym
  • Mecillinam (en)
  • Penicillin HX (en)
http://linked.open...ynthesisReference
  • U.S. Patent 3,957,764. (en)
http://linked.open...y/mesh/hasConcept
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Poorly absorbed if given orally. (en)
http://linked.open.../affectedOrganism
  • Gram-negative Bacteria (en)
  • Escherichia coli (en)
  • Proteus mirabilis (en)
  • Staphylococcus saprophyticus (en)
http://linked.open...casRegistryNumber
  • 32887-01-7 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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