About: Sertaconazole     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type
http://linked.open...gbank/description
  • Sertaconazole nitrate is an antifungal medication of the imidazole class. It is available as a cream to treat skin infections such as athlete's foot. [Wikipedia] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...ugbank/indication
  • For the topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, and <i>Epidermophyton floccosum</i>. (en)
sameAs
Title
  • Sertaconazole (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Sertaconazole interacts with 14-&alpha; demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Sertaconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. (en)
http://linked.open...drugbank/packager
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  • Sertaconazole (en)
  • Ertaczo (en)
  • Demofix (en)
  • Sertaconazol (en)
  • Sertaconazolum (en)
http://linked.open...nk/proteinBinding
  • >99% to plasma (en)
http://linked.open...y/mesh/hasConcept
foaf:page
http://linked.open...ugbank/IUPAC-Name
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http://linked.open...ugbank/absorption
  • Bioavailability is negligible. (en)
http://linked.open.../affectedOrganism
  • Yeast and other fungi (en)
http://linked.open...casRegistryNumber
  • 99592-32-2 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
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http://linked.open...-strongest-basic-
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