About: Flucytosine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A fluorinated cytosine analog that is used as an antifungal agent. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3EE5-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3EE6-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	2.4 to 4.8 hours. (en)
http://linked.open...ugbank/indication	For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections). (en)
sameAs	Flucytosine Flucytosine
Title	Flucytosine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/bindingdb/50241247 http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/chebi/5100 http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/chemspider/3249 http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/drugbank/DB01099 http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/kegg-drug/D00323 http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/national-drug-code-directory/0187-3554-10 http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/pharmgkb/PA449654 http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/pubchem-compound/3366 http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/pubchem-substance/46504735 http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/wikipedia/Flucytosine
http://linked.open...mechanismOfAction	Although the exact mode of action is unknown, it has been proposed that flucytosine acts directly on fungal organisms by competitive inhibition of purine and pyrimidine uptake and indirectly by intracellular metabolism to 5-fluorouracil. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. It also appears to be an inhibitor of fungal thymidylate synthase. (en)
http://linked.open...drugbank/packager	Caraco Pharmaceutical Labs Cardinal Health Carlisle Laboratories Inc. Pharmaceutical Utilization Management Program VA Inc.
http://linked.open...outeOfElimination	Flucytosine is excreted via the kidneys by means of glomerular filtration without significant tubular reabsorption. A small portion of the dose is excreted in the feces. (en)
http://linked.open.../drugbank/synonym	Flucytosine (en) 5-FC (en) 5-Fluorocystosine (en) 5-Fluorocytosin (en) 5-Fluorocytosine (en) 5-Flurocytosine (en) Flucytosin (en) Fluocytosine (en) Fluorcytosine (en) Ancobon (tn) (en)
http://linked.open...drugbank/toxicity	Oral, rat: LD<sub>50</sub> = >15 gm/kg. (en)
http://linked.open...nk/proteinBinding	28-31% (en)
http://linked.open...ynthesisReference	Bernd Baasner, Erich Klauke, "Process for the preparation of 5-fluorocytosine." U.S. Patent US4703121, issued September, 1961. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0008576
foaf:page	http://www.drugs.com/cdi/flucytosine.html http://www.rxlist.com/cgi/generic3/flucytosine.htm
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http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3EF0-363D-11E5-9242-09173F13E4C5
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http://linked.open...l/drug/hasATCCode	Flucytosine Flucytosine
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http://linked.open...ugbank/absorption	Rapidly and virtually completely absorbed following oral administration. Bioavailability 78% to 89%. (en)
http://linked.open.../affectedOrganism	Yeast and other fungi (en)
http://linked.open...casRegistryNumber	2022-85-7 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Ancobon 250 mg capsule Ancobon 500 mg capsule
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