About: Amprenavir     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Amprenavir is a protease inhibitor used to treat HIV infection. (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • 7.1-10.6 hours (en)
http://linked.open...ugbank/indication
  • For the treatment of HIV-1 infection in combination with other antiretroviral agents. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Amprenavir (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Amprenavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. (en)
http://linked.open...drugbank/packager
http://linked.open...y/drugbank/patent
http://linked.open.../drugbank/synonym
  • Amprenavir (en)
  • Agenerase (en)
  • Amprenavirum (en)
  • Amprénavir (en)
  • (3S)-Tetrahydro-3-furanyl ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)carbamate (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...k/foodInteraction
  • Take with or without food, however avoid lipid-rich meals. (en)
  • Vitamin E increases amprenavir bioavailability. (en)
  • Avoid alcohol, especially with the oral solution since it contains propylene glycol which competes with alcohol for alcohol dehydrogenase metabolism. (en)
http://linked.open...nk/proteinBinding
  • Very high (90%). Amprenavir has the highest affinity for alpha(1)-acid glycoprotein. (en)
http://linked.open...ynthesisReference
  • "DrugSyn.org":http://www.drugsyn.org/Amprenavir.htm (en)
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foaf:page
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  • Rapidly absorbed after oral administration in HIV-1-infected patients with a time to peak concentration (T<sub>max</sub>) typically between 1 and 2 hours after a single oral dose. The absolute oral bioavailability of amprenavir in humans has not been established. (en)
http://linked.open.../affectedOrganism
  • Human Immunodeficiency Virus (en)
http://linked.open...casRegistryNumber
  • 161814-49-9 (en)
http://linked.open...drugbank/category
  • (en)
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http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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