About: Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQ01, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population

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About: Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQ01, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The glutathione S-transferase Mu-1 deletion was associated with a moderately elevated colorectal cancer risk (aOR=1.30, CI=1.01-1.68, p=0.044). Combination of glutathione Stransferase Mu-1 and i-1 deletion was associated with a significantly higher colorectal cancer risk compared to the presence of both full-length genes (aOR=1.58, CI=1.01-2.47, p=0.044). These results provide further evidence that interaction between metabolic gene variants contributes to colorectal carcinogenesis. The glutathione S-transferase Mu-1 deletion was associated with a moderately elevated colorectal cancer risk (aOR=1.30, CI=1.01-1.68, p=0.044). Combination of glutathione Stransferase Mu-1 and i-1 deletion was associated with a significantly higher colorectal cancer risk compared to the presence of both full-length genes (aOR=1.58, CI=1.01-2.47, p=0.044). These results provide further evidence that interaction between metabolic gene variants contributes to colorectal carcinogenesis. (en)
Title	Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQ01, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQ01, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population (en)
skos:prefLabel	Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQ01, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQ01, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population (en)
skos:notation	RIV/75010330:_____/10:00008910!RIV11-GA0-75010330
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GA310/07/1430), P(NS10230), S, Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Souček, Pavel Hlavatá, Ivona Šmerhovský, Zdeněk Vrána, David Mohelníková-Duchoňová, Beatrice
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Státní zdravotní ústav, příspěvková organizace
http://linked.open...dnocenehoVysledku	247951
http://linked.open...ai/riv/idVysledku	RIV/75010330:_____/10:00008910
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colorectal cancer; cytochrome P450; polymorphism (en)
http://linked.open.../riv/klicoveSlovo	colorectal cancer polymorphism cytochrome P450
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[3B03240CAF09]
http://linked.open...i/riv/nazevZdroje	Oncology reports
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and genetic characteristics of sporadic colorectal cancer in the Czech Republic. Rationalization of strategy of oncological treatment of radically inoperable colorectal liver metastases
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Novotný, J. Šmerhovský, Zdeněk Souček, Pavel Hlavatá, Ivona Naccarati, A. Pardini, B. Vodička, P. Vrána, David Mohelníková-Duchoňová, Beatrice
http://linked.open...ain/vavai/riv/wos	000283112200031
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	1021-335X
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQ01, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQ01, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population

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