About: Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGF beta-Activated Kinase 1 Tyrosine Phosphorylation and NFkB Signaling in Multiple Myeloma and Bladder Cancer

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About: Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGF beta-Activated Kinase 1 Tyrosine Phosphorylation and NFkB Signaling in Multiple Myeloma and Bladder Cancer Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cancer is a major public health problem worldwide. In the United States alone, 1 in 4 deaths is due to cancer and for 2013 a total of 1,660,290 new cancer cases and 580,350 cancer-related deaths are projected. Comprehensive profiling of multiple cancer genomes has revealed a highly complex genetic landscape in which a large number of altered genes, varying from tumor to tumor, impact core biological pathways and processes. This has implications for therapeutic targeting of signaling networks in the development of treatments for specific cancers. The NF kappa B transcription factor is constitutively active in a number of hematologic and solid tumors, and many signaling pathways implicated in cancer are likely connected to NF kappa B activation. A critical mediator of NF kappa B activity is TGF beta-activated kinase 1 (TAK1). Here, we identify TAK1 as a novel interacting protein and target of fibroblast growth factor receptor 3 (FGFR3) tyrosine kinase activity. Cancer is a major public health problem worldwide. In the United States alone, 1 in 4 deaths is due to cancer and for 2013 a total of 1,660,290 new cancer cases and 580,350 cancer-related deaths are projected. Comprehensive profiling of multiple cancer genomes has revealed a highly complex genetic landscape in which a large number of altered genes, varying from tumor to tumor, impact core biological pathways and processes. This has implications for therapeutic targeting of signaling networks in the development of treatments for specific cancers. The NF kappa B transcription factor is constitutively active in a number of hematologic and solid tumors, and many signaling pathways implicated in cancer are likely connected to NF kappa B activation. A critical mediator of NF kappa B activity is TGF beta-activated kinase 1 (TAK1). Here, we identify TAK1 as a novel interacting protein and target of fibroblast growth factor receptor 3 (FGFR3) tyrosine kinase activity. (en)
Title	Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGF beta-Activated Kinase 1 Tyrosine Phosphorylation and NFkB Signaling in Multiple Myeloma and Bladder Cancer Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGF beta-Activated Kinase 1 Tyrosine Phosphorylation and NFkB Signaling in Multiple Myeloma and Bladder Cancer (en)
skos:prefLabel	Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGF beta-Activated Kinase 1 Tyrosine Phosphorylation and NFkB Signaling in Multiple Myeloma and Bladder Cancer Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGF beta-Activated Kinase 1 Tyrosine Phosphorylation and NFkB Signaling in Multiple Myeloma and Bladder Cancer (en)
skos:notation	RIV/68081707:_____/14:00440592!RIV15-AV0-68081707
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Krejčí, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	16690
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/14:00440592
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	FACTOR-KAPPA-B; URINARY-BLADDER; DOWN-REGULATION (en)
http://linked.open.../riv/klicoveSlovo	DOWN-REGULATION FACTOR-KAPPA-B URINARY-BLADDER
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B04A36922188]
http://linked.open...i/riv/nazevZdroje	PLoS ONE
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Krejčí, Pavel Wilcox, W. R. Thompson, L. M. Casale, M. Donoghue, D. J. Hallowell, M. Kashiwada, T. Meyer, A. N. Salazar, L.
http://linked.open...ain/vavai/riv/wos	000330288000101
issn	1932-6203
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0086470

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