About: CDC25A phosphatase controls meiosis I progression in mouse oocytes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This paper uses functional studies (RNAi, mRNA microinjection) to uncover a role of CDC25A in female meiosis. CDC25A cooperates together with CDC25B during resumption of meiosis, destruction of CDC25A in prometaphase I is crucial for MI-MII transition. CDC25A is exclusively localized to the nucleus prior to nuclear envelope breakdown (NEBD). In contrast, CDC25B localizes to cytoplasm in GV-intact oocytes and translocates to the nucleus shortly before NEBD. CDC25A behaves differently during female meiosis than during mitosis, and moreover, that CDC25A has a function in resumption of meiosis, MI spindle formation and the MI–MII transition. Thus, both CDC25A and CDC25B are critical for meiotic maturation of oocytes. This paper uses functional studies (RNAi, mRNA microinjection) to uncover a role of CDC25A in female meiosis. CDC25A cooperates together with CDC25B during resumption of meiosis, destruction of CDC25A in prometaphase I is crucial for MI-MII transition. CDC25A is exclusively localized to the nucleus prior to nuclear envelope breakdown (NEBD). In contrast, CDC25B localizes to cytoplasm in GV-intact oocytes and translocates to the nucleus shortly before NEBD. CDC25A behaves differently during female meiosis than during mitosis, and moreover, that CDC25A has a function in resumption of meiosis, MI spindle formation and the MI–MII transition. Thus, both CDC25A and CDC25B are critical for meiotic maturation of oocytes. (en) Práce pomocí funkčních studií (RNAi, mRNA mikroinjekce) objasňuje roli CDC25A v samičí meióze. CDC25A se spolu s CDC25B podílí na znovuzahájení meiózy, destrukce CDC25A v prometafázi I je klíčová pro MI-MII přechod. CDC25A je před znovuzahájením meiózy čistě jaderný protein, avšak CDC25B je nejdříve lokalizována do cytoplasmy a těsně před rozpadem jaderné membrány se translokuje do jádra. CDC25A hraje klíčovou roli v znovuzahájení meiózy, v tvorbě MI spindlu a MI-MII přechodu. (cs)
Title	CDC25A phosphatase controls meiosis I progression in mouse oocytes CDC25A phosphatase controls meiosis I progression in mouse oocytes (en) CDC25A fosfatáza reguluje průchod meiózou I v myších oocytech (cs)
skos:prefLabel	CDC25A phosphatase controls meiosis I progression in mouse oocytes CDC25A phosphatase controls meiosis I progression in mouse oocytes (en) CDC25A fosfatáza reguluje průchod meiózou I v myších oocytech (cs)
skos:notation	RIV/67985904:_____/08:00307953!RIV08-AV0-67985904
http://linked.open.../vavai/riv/strany	260;269
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/06/1413), P(GD204/05/H023), Z(AV0Z50450515)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Motlík, Jan Kubelka, Michal Šolc, Petr Šašková, Adéla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	358966
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/08:00307953
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	resumption of meiosis; meiotic maturation; mouse oocytes (en)
http://linked.open.../riv/klicoveSlovo	mouse oocytes meiotic maturation resumption of meiosis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D81323E25E44]
http://linked.open...i/riv/nazevZdroje	Developmental Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of protein kinase Aurora-A in resumption of meiosis of mouse oocytes. Molecular biology of differentiating cell
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	317
http://linked.open...iv/tvurceVysledku	Motlík, Jan Kubelka, Michal Šolc, Petr Schultz, R. M. Šašková, Adéla Baran, V.
http://linked.open...n/vavai/riv/zamer	Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture
issn	0012-1606
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	CDC25A phosphatase controls meiosis I progression in mouse oocytes CDC25A phosphatase controls meiosis I progression in mouse oocytes CDC25A phosphatase controls meiosis I progression in mouse oocytes CDC25A phosphatase controls meiosis I progression in mouse oocytes

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