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| rdf:type
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| Description
| - The quaternary benzo[c]phenanthridine alkaloid sanguinarine (SG) is the main component of Sangrovit, a natural livestock feed additive. Dihydrosanguinarine (DHSG) has recently been identified as a SG metabolite in rat. The conversion of SG to DHSG is a likely elimination pathway of SG in mammals. This study was conducted to evaluate the toxicity of DHSG in male Wistar rats at concentrations of 100 and 500 ppm DHSG in feed for 90 days (average doses of 14 and 58 mg DHSG/kg body weight/day). No significant alterations in body or organ weights, macroscopic details of organs, histopathology of liver, ileum, kidneys, tongue, heart or gingiva, clinical chemistry or hematology markers in blood in the DHSG-treated animals were found compared to controls. No lymphocyte DNA damage by Comet assay, formation of DNA adducts in liver by 32P-postlabeling, modulation of cytochrome P450 1A1/2 or changes in oxidative stress parameters were found. Thus, repeated dosing of DHSG for 90 days at up to 500 ppm in t
- The quaternary benzo[c]phenanthridine alkaloid sanguinarine (SG) is the main component of Sangrovit, a natural livestock feed additive. Dihydrosanguinarine (DHSG) has recently been identified as a SG metabolite in rat. The conversion of SG to DHSG is a likely elimination pathway of SG in mammals. This study was conducted to evaluate the toxicity of DHSG in male Wistar rats at concentrations of 100 and 500 ppm DHSG in feed for 90 days (average doses of 14 and 58 mg DHSG/kg body weight/day). No significant alterations in body or organ weights, macroscopic details of organs, histopathology of liver, ileum, kidneys, tongue, heart or gingiva, clinical chemistry or hematology markers in blood in the DHSG-treated animals were found compared to controls. No lymphocyte DNA damage by Comet assay, formation of DNA adducts in liver by 32P-postlabeling, modulation of cytochrome P450 1A1/2 or changes in oxidative stress parameters were found. Thus, repeated dosing of DHSG for 90 days at up to 500 ppm in t (en)
- Kvartérní benzo[c]fenanthridinový alkaloid sanguinarin (SG) je hlavní složkou Sangrovitu, přídavku do krmiva pro dobytek. Dihydrosanguinarin (DHSG) byl recentně identifikován jako metabolit SG u potkana. Přeměna SG na DHSG je pravděpodobně eliminační dráha SG u savců. Tato studie byla prováděna s cílem hodnotit toxicitu DHSG u potkaních samců kmene Wistar rats krmených 90 dní 100 a 500 ppm DHSG (průměrné dávky 14 a 58 mg DHSG/kg tělesné hmotnosti/den). Ve srovnání s kontrolní skupinou nebyly u zvířat krmených DHSG zaznamenány změny v tělesné hmotnosti a hmotnosti orgánů, makroskopických detailech orgánů, histopatologii jater, ilea, ledvin, jazyka, srdce nebo gingivy a klinicko biochemických markerů v krvi. Nebylo nalezeno žádné poškození DNA v lymfocytech pomocí Comet assay, tvorba DNA duktů v játrech pomocí 32P-postlabeling, modulace cytochromu P450 1A1/2 nebo změny v parametrech oxidačního stresu. Tedy opakované dávkování DHSG po 90 dní v koncentracích do 500 ppm v potravě (i.e. cca 58 mg/kg/den) ne (cs)
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| Title
| - The toxicity and pharmacokinetics of dihydrosanguinarine in rat: A pilot study.
- The toxicity and pharmacokinetics of dihydrosanguinarine in rat: A pilot study. (en)
- Toxicita a farmakokinetika dihydrosanguinarinu u potkana: Pilotní studie. (cs)
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| skos:prefLabel
| - The toxicity and pharmacokinetics of dihydrosanguinarine in rat: A pilot study.
- The toxicity and pharmacokinetics of dihydrosanguinarine in rat: A pilot study. (en)
- Toxicita a farmakokinetika dihydrosanguinarinu u potkana: Pilotní studie. (cs)
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| skos:notation
| - RIV/61989592:15310/08:00005340!RIV09-MSM-15310___
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA525/07/0871), Z(MSM6198959216)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| - Lichnovský, Václav
- Šimánek, Vilím
- VEČEŘA, Rostislav
- ANZENBACHER, Pavel
- VIČAR, Jaroslav
- Rajnochová Svobodová, Alena
- Ulrichová, Jitka
- Galandáková, Adéla
- Vostálová, Jitka
- Kosina, Pavel
- Dvořák, Zdeněk
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15310/08:00005340
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Benzo[c]phenanthridine alkaloid; Dihydrosanguinarine; Sanguinarine; Dietary toxicity; Metabolism; Disposition. (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Food and Chemical Toxicology
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Dvořák, Zdeněk
- Kosina, Pavel
- Stejskal, David
- Ulrichová, Jitka
- Vostálová, Jitka
- Anzenbacher, Pavel
- Klejdus, Bořivoj
- Šimánek, Vilím
- Večeřa, Rostislav
- Vrublová, Eva
- Svobodová, Alena
- Vičar, Jaroslav
- Lichnovský, Václav
- Zdařilová, Adéla
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
| |
| is http://linked.open...avai/riv/vysledek
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