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| Description
| - Vysoce dávkovaná chemoterapie následovaná autologní transplantací kostní dřeně v 1. kompletní remisi zlepšila přežití pacientů s prognosticky nepříznivým difuzním velkobuněčným B-lymfomem.Retrospektivně jsme hodnotili výsledky léčby vysoce dávkovanou chemoterapií následovanou autologní transplantací kostní dřeně u 55 pacientů. Výsledky ukazují, že tato strategie je efektivní možností léčby pacientů mladších 65 let s nepříznivým difuzním velkobuněčným B lymfomem v kompletní nebo parciální remisí, dokonce i v éře R-chemoterapie. (cs)
- Improved survival has been observed in poor-risk diffuse large B-cell lymphoma (DLBCL) patients treated with high-dose therapy /HDT) followed by autologous stem cell transplantation (ASCT) in firts complete remission. Reprospective studies hase suggested that HDT with ASCT can improve survival also in partial responders but some doubt about the advantage of intensive therapy in such patients still remain. We evaluated retrospectively the results of hDT and ASCT in 55 patients with confirmed DLBCL treated between may 1999 and July 2006. Thirty-six patients (65%) showed partial remission (PR) and 19 patients (35%) reached complete remission (CR) after induction treatment with (44%) or without (56%) concomitant ritusimab (R) immunotherapy. After HDT a ASCT, 69% of patients fulfilled the criteria of CR, 22 % had unconfirmed CR (CRu), 7%remained in PR and 1 patient (2%) relapsed. Twenty patients in PR after the induction treatment reached CR after ASCT, 12 other PR patients achieved CRu. The 5-year event-f
- Improved survival has been observed in poor-risk diffuse large B-cell lymphoma (DLBCL) patients treated with high-dose therapy /HDT) followed by autologous stem cell transplantation (ASCT) in firts complete remission. Reprospective studies hase suggested that HDT with ASCT can improve survival also in partial responders but some doubt about the advantage of intensive therapy in such patients still remain. We evaluated retrospectively the results of hDT and ASCT in 55 patients with confirmed DLBCL treated between may 1999 and July 2006. Thirty-six patients (65%) showed partial remission (PR) and 19 patients (35%) reached complete remission (CR) after induction treatment with (44%) or without (56%) concomitant ritusimab (R) immunotherapy. After HDT a ASCT, 69% of patients fulfilled the criteria of CR, 22 % had unconfirmed CR (CRu), 7%remained in PR and 1 patient (2%) relapsed. Twenty patients in PR after the induction treatment reached CR after ASCT, 12 other PR patients achieved CRu. The 5-year event-f (en)
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| Title
| - High-dose therapy and autologous stem cell transplantation in patients with diffuse large B-cell lymphoma in first complete or partial remission
- High-dose therapy and autologous stem cell transplantation in patients with diffuse large B-cell lymphoma in first complete or partial remission (en)
- Vysoce dávkovaná terapie a autologní transplantace u pacientů s difuzním velkobuněčným B lymfomem v 1. kompletní nebo parciální remisi (cs)
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| skos:prefLabel
| - High-dose therapy and autologous stem cell transplantation in patients with diffuse large B-cell lymphoma in first complete or partial remission
- High-dose therapy and autologous stem cell transplantation in patients with diffuse large B-cell lymphoma in first complete or partial remission (en)
- Vysoce dávkovaná terapie a autologní transplantace u pacientů s difuzním velkobuněčným B lymfomem v 1. kompletní nebo parciální remisi (cs)
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| skos:notation
| - RIV/61989592:15110/08:00007645!RIV09-MSM-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
| - Raida, Luděk
- Vondráková, Jana
- Skoumalová, Ivana
- Neoral, Čestmír
- PAPAJÍK, Tomáš
- MYSLIVEČEK, Miroslav
- Faber, Edgar
- Procházka, Vít
- Kučerová, Ladislava
- Jarošová, Marie
- Tichý, Martin
- Pauček, Boris
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/08:00007645
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - diffuse large B-cell lymphoma; autologous transplantation; rituximab; survival (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Dušek, Ladislav
- Faber, Edgar
- Jarkovský, J.
- Jarošová, Marie
- Kubová, Zuzana
- Neoral, Čestmír
- Raida, Luděk
- Skoumalová, Ivana
- Vondráková, Jana
- Procházka, Vít
- Kučerová, Ladislava
- Papajík, Tomáš
- Tichý, Martin
- Mysliveček, Miroslav
- Pauček, Boris
- Oral, Ivo
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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