About: Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes

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About: Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Composite microparticles consisting of a calcium alginate gel matrix with embedded liposomes made from cholesterol:DPPC (dipalmitoylphosphatidylcholine) mixtures were considered. Factors affecting the encapsulation stability of liposomes during the gel formation by ionic cross-linking ? namely temperature and the cholesterol:DPPC ratio ? were systematically investigated. The liposomes were found to be tolerant to Ca2+ ions during cross-linking of the gel and stable in the hydrogel matrix for extended periods of time when cholesterol was present in the phospholipid bilayer and temperature was kept sufficiently below the phase transition. The temperature-controlled release rate of encapsulated fluorescent dye was quantified. It is shown that a defined quantity of encapsulated substance can be repeatedly released from the embedded liposomes ?on-demand? by short temperature pulses of suitably chosen duration and amplitude. This makes the hydrogel?liposome composites potential candidates for applications such as controlled drug delivery or study of reaction?diffusion phenomena in compartmentalised systems. Composite microparticles consisting of a calcium alginate gel matrix with embedded liposomes made from cholesterol:DPPC (dipalmitoylphosphatidylcholine) mixtures were considered. Factors affecting the encapsulation stability of liposomes during the gel formation by ionic cross-linking ? namely temperature and the cholesterol:DPPC ratio ? were systematically investigated. The liposomes were found to be tolerant to Ca2+ ions during cross-linking of the gel and stable in the hydrogel matrix for extended periods of time when cholesterol was present in the phospholipid bilayer and temperature was kept sufficiently below the phase transition. The temperature-controlled release rate of encapsulated fluorescent dye was quantified. It is shown that a defined quantity of encapsulated substance can be repeatedly released from the embedded liposomes ?on-demand? by short temperature pulses of suitably chosen duration and amplitude. This makes the hydrogel?liposome composites potential candidates for applications such as controlled drug delivery or study of reaction?diffusion phenomena in compartmentalised systems. (en)
Title	Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes (en)
skos:prefLabel	Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes (en)
skos:notation	RIV/60461373:22340/13:43895520!RIV14-MSM-22340___
http://linked.open...avai/predkladatel	Fakulta chemicko-inženýrská
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	15 March 2013
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Štěpánek, František Dohnal, Jiří Hanuš, Jaroslav Ullrich, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	72757
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/13:43895520
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Diffusion; Controlled release; Alginate; Hydrogel; Liposomes (en)
http://linked.open.../riv/klicoveSlovo	Liposomes Controlled release Alginate Diffusion Hydrogel
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[91CEEC9E8C79]
http://linked.open...i/riv/nazevZdroje	Journal of Colloid and Interface Science
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	394
http://linked.open...iv/tvurceVysledku	Dohnal, Jiří Štěpánek, František Hanuš, Jaroslav Ullrich, Martin
http://linked.open...ain/vavai/riv/wos	000315325400048
issn	0021-9797
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jcis.2012.11.016
http://localhost/t...ganizacniJednotka	22340

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