About: Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs

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About: Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://rnajournal.cshlp.org/content/early/2013/10/18/rna.040055.113.abstract
Description	The mechanisms of gene expression regulation by miRNAs have been extensively studied. However, the regulation of miRNA function and decay has long remained enigmatic. Only recently, 3'uridylation via LIN28A-TUT4/7 has been recognized as an essential component controlling the biogenesis of let-7 miRNAs in stem cells. Although uridylation has been generally implicated in miRNA degradation, the nuclease responsible has remained unknown. Here, we identify the Perlman syndromeassociated protein DIS3L2 as an oligo(U)-binding and processing exoribonuclease that specifically targets uridylated pre-let-7 in vivo. This study establishes DIS3L2 as the missing component of the LIN28-TUT4/7-DIS3L2 pathway required for the repression of let-7 in pluripotent cells. The mechanisms of gene expression regulation by miRNAs have been extensively studied. However, the regulation of miRNA function and decay has long remained enigmatic. Only recently, 3'uridylation via LIN28A-TUT4/7 has been recognized as an essential component controlling the biogenesis of let-7 miRNAs in stem cells. Although uridylation has been generally implicated in miRNA degradation, the nuclease responsible has remained unknown. Here, we identify the Perlman syndromeassociated protein DIS3L2 as an oligo(U)-binding and processing exoribonuclease that specifically targets uridylated pre-let-7 in vivo. This study establishes DIS3L2 as the missing component of the LIN28-TUT4/7-DIS3L2 pathway required for the repression of let-7 in pluripotent cells. (en)
Title	Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs (en)
skos:prefLabel	Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs (en)
skos:notation	RIV/00216224:14740/13:00066446!RIV14-MSM-14740___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(GAP305/11/1095), P(GBP206/12/G151), P(GBP305/12/G034)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Chalupníková, Kateřina Ustianenko, Dmytro Uldrijan, Stjepan Zdráhal, Zbyněk Pacherník, Jiří Vaňáčová, Štěpánka Hroššová, Dominika Hrazdilová, Kristýna Potěšil, David Cetkovská, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	85868
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00066446
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DIS3L2; RNA degradation; RNA uridylation; let-7 miRNA (en)
http://linked.open.../riv/klicoveSlovo	RNA degradation DIS3L2 RNA uridylation let-7 miRNA
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[39EC27C33F22]
http://linked.open...i/riv/nazevZdroje	RNA
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional and biochemical characterization of Dis3L2, the third mammalian homolog of the key yeast exosome nuclease Dis3p Center of novel approaches to bioanalysis and molecular diagnostics Centre for RNA Biology Central european institute of technology
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Pacherník, Jiří Uldrijan, Stjepan Zdráhal, Zbyněk Hroššová, Dominika Vaňáčová, Štěpánka Hrazdilová, Kristýna Potěšil, David Cetkovská, Kateřina Chalupníková, Kateřina Ustianenko, Dmytro
http://linked.open...ain/vavai/riv/wos	000327445700004
issn	1355-8382
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1261/rna.040055.113
http://localhost/t...ganizacniJednotka	14740

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