About: Adsorption of cisplatin on plasma trated sufaces: a mass spectrometric study

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cisplatin (Fig. 1) is widely used as anti tumor drug. It shows several side effects, in particular neuro and nephro toxicity [1,2]. It affects the DNA, RNA, or protein synthesis. Therefore, cisplatin was classified by the International Agency for Research on Cancer (IARC) as carcinogenic, mutagenic, and teratogenic compound for humans. Potential health risk for people arises from direct contact, contamination of the work area or of packaging material [3]. For this reason, side effects due to occupational exposure to cisplatin have been reported with increasing frequency [4]. Fig. 1: Chemical structure of cisplatin. It has been shown that drug vials may already be contaminated with cisplatin when delivered from the manufacturer [5]. In addition, theoretical studies have shown that cisplatin may interact with hydrated silica [6]. The surface properties and the chemical composition of the materials used to store and handle cisplatin influence its adsorption. Cisplatin (Fig. 1) is widely used as anti tumor drug. It shows several side effects, in particular neuro and nephro toxicity [1,2]. It affects the DNA, RNA, or protein synthesis. Therefore, cisplatin was classified by the International Agency for Research on Cancer (IARC) as carcinogenic, mutagenic, and teratogenic compound for humans. Potential health risk for people arises from direct contact, contamination of the work area or of packaging material [3]. For this reason, side effects due to occupational exposure to cisplatin have been reported with increasing frequency [4]. Fig. 1: Chemical structure of cisplatin. It has been shown that drug vials may already be contaminated with cisplatin when delivered from the manufacturer [5]. In addition, theoretical studies have shown that cisplatin may interact with hydrated silica [6]. The surface properties and the chemical composition of the materials used to store and handle cisplatin influence its adsorption. (en)
Title	Adsorption of cisplatin on plasma trated sufaces: a mass spectrometric study Adsorption of cisplatin on plasma trated sufaces: a mass spectrometric study (en)
skos:prefLabel	Adsorption of cisplatin on plasma trated sufaces: a mass spectrometric study Adsorption of cisplatin on plasma trated sufaces: a mass spectrometric study (en)
skos:notation	RIV/00216224:14310/12:00078230!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0086), S
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Skácelová, Dana Amato, Filippo Pivetta, Tiziana
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	121150
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/12:00078230
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cisplatin; adsorption; mass spectrometry (en)
http://linked.open.../riv/klicoveSlovo	adsorption mass spectrometry cisplatin
http://linked.open...ontrolniKodProRIV	[5E67DED896EB]
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Regional R&D center for low-cost plasma and nanotechnology surface modifications
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Amato, Filippo Havel, Josef Skácelová, Dana Pivetta, Tiziana
http://localhost/t...ganizacniJednotka	14310

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